PDB entry 2amf

View 2amf on RCSB PDB site
Description: Crystal structure of 1-Pyrroline-5-Carboxylate Reductase from Human Pathogen Streptococcus Pyogenes
Class: oxidoreductase
Keywords: 1-Pyrroline-5-Reductase, Pyrroline-5-Carboxylate Reductase, Pyrroline Reductase, Proline biosynthesis, NAD(P)binding protein, Rossmann Fold, Domain swapping, human pathogen, Streptococcus pyogenes, Structural Genomics, MCSG, PSI, Protein Structure Initiative, Midwest Center for Structural Genomics, OXIDOREDUCTASE
Deposited on 2005-08-09, released 2005-09-27
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.175
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 1-Pyrroline-5-Carboxylate reductase
    Species: STREPTOCOCCUS PYOGENES [TaxId:160490]
    Gene: proC
    Database cross-references and differences (RAF-indexed):
    • GB AAK33229 (3-258)
      • cloning artifact (2)
    Domains in SCOPe 2.05: d2amfa1, d2amfa2
  • Chain 'B':
    Compound: 1-Pyrroline-5-Carboxylate reductase
    Species: STREPTOCOCCUS PYOGENES [TaxId:160490]
    Gene: proC
    Database cross-references and differences (RAF-indexed):
    • GB AAK33229 (3-258)
      • cloning artifact (2)
    Domains in SCOPe 2.05: d2amfb1, d2amfb2
  • Chain 'C':
    Compound: 1-Pyrroline-5-Carboxylate reductase
    Species: STREPTOCOCCUS PYOGENES [TaxId:160490]
    Gene: proC
    Database cross-references and differences (RAF-indexed):
    • GB AAK33229 (3-258)
    Domains in SCOPe 2.05: d2amfc1, d2amfc2
  • Chain 'D':
    Compound: 1-Pyrroline-5-Carboxylate reductase
    Species: STREPTOCOCCUS PYOGENES [TaxId:160490]
    Gene: proC
    Database cross-references and differences (RAF-indexed):
    • GB AAK33229 (3-258)
      • cloning artifact (1-2)
    Domains in SCOPe 2.05: d2amfd1, d2amfd2
  • Chain 'E':
    Compound: 1-Pyrroline-5-Carboxylate reductase
    Species: STREPTOCOCCUS PYOGENES [TaxId:160490]
    Gene: proC
    Database cross-references and differences (RAF-indexed):
    • GB AAK33229 (3-258)
      • cloning artifact (0-2)
    Domains in SCOPe 2.05: d2amfe1, d2amfe2
  • Heterogens: NA, PRO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2amfA (A:)
snamkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidq
vdlvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqil
qsstaltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfieala
kagvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlg
ltatvssaidktidkaksl

    Sequence, based on observed residues (ATOM records): (download) 
    >2amfA (A:)
amkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidqvd
lvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqilqs
staltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfiealaka
gvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlglt
atvssaidktidkaksl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2amfB (B:)
snamkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidq
vdlvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqil
qsstaltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfieala
kagvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlg
ltatvssaidktidkaksl

    Sequence, based on observed residues (ATOM records): (download) 
    >2amfB (B:)
amkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidqvd
lvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqilqs
staltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfiealaka
gvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlglt
atvssaidktidkaksl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2amfC (C:)
snamkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidq
vdlvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqil
qsstaltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfieala
kagvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlg
ltatvssaidktidkaksl

    Sequence, based on observed residues (ATOM records): (download) 
    >2amfC (C:)
mkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidqvdl
vilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqilqss
taltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfiealakag
vkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlglta
tvssaidktidkaksl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2amfD (D:)
snamkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidq
vdlvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqil
qsstaltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfieala
kagvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlg
ltatvssaidktidkaksl

    Sequence, based on observed residues (ATOM records): (download) 
    >2amfD (D:)
namkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidqv
dlvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqilq
sstaltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfiealak
agvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlgl
tatvssaidktidkaksl

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2amfE (E:)
snamkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidq
vdlvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqil
qsstaltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfieala
kagvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlg
ltatvssaidktidkaksl