PDB entry 2ahr

View 2ahr on RCSB PDB site
Description: Crystal Structures of 1-Pyrroline-5-Carboxylate Reductase from Human Pathogen Streptococcus pyogenes
Class: oxidoreductase
Keywords: 1-Pyrroline-5-Carboxylate Reductase, Pyrroline-5-Carboxylate Reductase, Pyrroline Reductase, Proline biosynthesis, NAD(P)binding protein, Rossmann Fold, Doain swapping, human pathogen, Streptococcus pyogenes, Structural Genomics, MCSG, PSI, Protein Structure Initiative, Midwest Center for Structural Genomics, OXIDOREDUCTASE
Deposited on 2005-07-28, released 2005-09-13
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.175
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: putative pyrroline carboxylate reductase
    Species: STREPTOCOCCUS PYOGENES [TaxId:160490]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9A1S9 (3-258)
      • cloning artifact (2)
      • modified residue (3)
      • modified residue (13)
      • modified residue (51)
      • modified residue (88)
      • modified residue (111)
      • modified residue (114)
      • modified residue (233)
    Domains in SCOPe 2.05: d2ahra1, d2ahra2
  • Chain 'B':
    Compound: putative pyrroline carboxylate reductase
    Species: STREPTOCOCCUS PYOGENES [TaxId:160490]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9A1S9 (3-258)
      • cloning artifact (2)
      • modified residue (3)
      • modified residue (13)
      • modified residue (51)
      • modified residue (88)
      • modified residue (111)
      • modified residue (114)
      • modified residue (233)
    Domains in SCOPe 2.05: d2ahrb1, d2ahrb2
  • Chain 'C':
    Compound: putative pyrroline carboxylate reductase
    Species: STREPTOCOCCUS PYOGENES [TaxId:160490]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9A1S9 (3-258)
      • modified residue (3)
      • modified residue (13)
      • modified residue (51)
      • modified residue (88)
      • modified residue (111)
      • modified residue (114)
      • modified residue (233)
    Domains in SCOPe 2.05: d2ahrc1, d2ahrc2
  • Chain 'D':
    Compound: putative pyrroline carboxylate reductase
    Species: STREPTOCOCCUS PYOGENES [TaxId:160490]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9A1S9 (3-258)
      • cloning artifact (1-2)
      • modified residue (3)
      • modified residue (13)
      • modified residue (51)
      • modified residue (88)
      • modified residue (111)
      • modified residue (114)
      • modified residue (233)
    Domains in SCOPe 2.05: d2ahrd1, d2ahrd2
  • Chain 'E':
    Compound: putative pyrroline carboxylate reductase
    Species: STREPTOCOCCUS PYOGENES [TaxId:160490]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9A1S9 (3-258)
      • cloning artifact (0-2)
      • modified residue (3)
      • modified residue (13)
      • modified residue (51)
      • modified residue (88)
      • modified residue (111)
      • modified residue (114)
      • modified residue (233)
    Domains in SCOPe 2.05: d2ahre1, d2ahre2
  • Heterogens: NA, NAP, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ahrA (A:)
snamkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidq
vdlvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqil
qsstaltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfieala
kagvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlg
ltatvssaidktidkaksl

    Sequence, based on observed residues (ATOM records): (download) 
    >2ahrA (A:)
amkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidqvd
lvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqilqs
staltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfiealaka
gvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlglt
atvssaidktidkaksl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ahrB (B:)
snamkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidq
vdlvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqil
qsstaltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfieala
kagvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlg
ltatvssaidktidkaksl

    Sequence, based on observed residues (ATOM records): (download) 
    >2ahrB (B:)
amkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidqvd
lvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqilqs
staltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfiealaka
gvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlglt
atvssaidktidkaksl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2ahrC (C:)
snamkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidq
vdlvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqil
qsstaltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfieala
kagvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlg
ltatvssaidktidkaksl

    Sequence, based on observed residues (ATOM records): (download) 
    >2ahrC (C:)
mkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidqvdl
vilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqilqss
taltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfiealakag
vkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlglta
tvssaidktidkaksl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2ahrD (D:)
snamkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidq
vdlvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqil
qsstaltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfieala
kagvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlg
ltatvssaidktidkaksl

    Sequence, based on observed residues (ATOM records): (download) 
    >2ahrD (D:)
namkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidqv
dlvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqilq
sstaltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfiealak
agvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlgl
tatvssaidktidkaksl

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ahrE (E:)
snamkigiigvgkmasaiikglkqtpheliisgsslerskeiaeqlalpyamshqdlidq
vdlvilgikpqlfetvlkplhfkqpiismaagislqrlatfvgqdlpllrimpnmnaqil
qsstaltgnalvsqelqarvrdltdsfgstfdisekdfdtftalagsspayiylfieala
kagvkngipkakaleivtqtvlasasnlktssqsphdfidaicspggttiaglmelerlg
ltatvssaidktidkaksl