PDB entry 2afm

View 2afm on RCSB PDB site
Description: Crystal structure of human glutaminyl cyclase at pH 6.5
Class: transferase
Keywords: alpha-beta protein, metalloprotein, TRANSFERASE
Deposited on 2005-07-26, released 2005-08-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.66 Å
R-factor: 0.182
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutaminyl-peptide cyclotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: QPCT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2afma1
  • Chain 'B':
    Compound: Glutaminyl-peptide cyclotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: QPCT
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2afmb_
  • Heterogens: ZN, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2afmA (A:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgeeaflhwspqds
lygsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlq
aiehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtm
ddneenldestidnlnkilqvfvleylhl

    Sequence, based on observed residues (ATOM records): (download) 
    >2afmA (A:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslkpdlslqliffdgeeaflhwspqdslygsrh
laakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaiehel
helgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddneen
ldestidnlnkilqvfvleylhl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2afmB (B:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgeeaflhwspqds
lygsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlq
aiehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtm
ddneenldestidnlnkilqvfvleylhl

    Sequence, based on observed residues (ATOM records): (download) 
    >2afmB (B:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslkpdlslqliffdgeeaflhwspqdslygsrh
laakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaiehel
helgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddneen
ldestidnlnkilqvfvleylhl