PDB entry 2aax

View 2aax on RCSB PDB site
Description: Mineralocorticoid Receptor Double Mutant with Bound Cortisone
Class: transcription
Keywords: Mineralocorticoid receptor, MR, Nuclear Receptor, Steroid Receptor, Cortisone, Hypertension, TRANSCRIPTION
Deposited on 2005-07-14, released 2005-07-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mineralocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C2, MCR, MLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08235
      • engineered (98)
      • engineered (100)
    Domains in SCOPe 2.08: d2aaxa_
  • Chain 'B':
    Compound: Mineralocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C2, MCR, MLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08235
      • engineered (98)
      • engineered (100)
    Domains in SCOPe 2.08: d2aaxb_
  • Heterogens: SO4, PDN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2aaxA (A:)
gsapakepsvntalvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstl
nrlagkqmiqvvkwakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyf
apdlvfneekmhqsamyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksq
aafeemrtnyikelrkmvtkcpnnsgqswqrfyqltklldsmhdlvsdllefcfytfres
halkvefpamlveiisdqlpkvesgnakplyfhrk

    Sequence, based on observed residues (ATOM records): (download) 
    >2aaxA (A:)
alvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvv
kwakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyfapdlvfneekmh
qsamyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyik
elrkmvtkcnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlve
iisdqlpkvesgnakplyfhr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2aaxB (B:)
gsapakepsvntalvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstl
nrlagkqmiqvvkwakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyf
apdlvfneekmhqsamyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksq
aafeemrtnyikelrkmvtkcpnnsgqswqrfyqltklldsmhdlvsdllefcfytfres
halkvefpamlveiisdqlpkvesgnakplyfhrk

    Sequence, based on observed residues (ATOM records): (download) 
    >2aaxB (B:)
lvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvk
wakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyfapdlvfneekmhq
samyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyike
lrkmvtnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiis
dqlpkvesgnakplyfh