SCOPe 2.05: Structural Classification of Proteins

PDB entry 2a6h

View 2a6h on RCSB PDB site
Description: Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin
Class: transferase
Keywords: RNA POLYMERASE HOLOENZYME, STREPTOLYDIGIN, ANTIBIOTIC, TRANSCRIPTION REGULATION, RIKEN Structural Genomics/Proteomics Initiative, RSGI, Structural Genomics, TRANSFERASE
Deposited on 2005-07-02, released 2005-09-20
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.23
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: DNA-directed RNA polymerase alpha chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q5SHR6 (0-End)
Domains in SCOPe 2.05: d2a6ha1, d2a6ha2
Chain 'B':
Compound: DNA-directed RNA polymerase alpha chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q5SHR6 (0-End)
Domains in SCOPe 2.05: d2a6hb1, d2a6hb2
Chain 'C':
Compound: DNA-directed RNA polymerase beta chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE9 (0-1118)
Domains in SCOPe 2.05: d2a6hc_
Chain 'D':
Compound: DNA-directed RNA polymerase beta' chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE8
Domains in SCOPe 2.05: d2a6hd_
Chain 'E':
Compound: RNA polymerase omega chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE7
Domains in SCOPe 2.05: d2a6he_
Chain 'F':
Compound: RNA polymerase sigma factor rpoD
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q5SKW1 (Start-422)
Domains in SCOPe 2.05: d2a6hf1, d2a6hf2, d2a6hf3
Chain 'K':
Compound: DNA-directed RNA polymerase alpha chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q5SHR6 (0-End)
Domains in SCOPe 2.05: d2a6hk1, d2a6hk2
Chain 'L':
Compound: DNA-directed RNA polymerase alpha chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q5SHR6 (0-End)
Domains in SCOPe 2.05: d2a6hl1, d2a6hl2
Chain 'M':
Compound: DNA-directed RNA polymerase beta chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE9 (0-1118)
Domains in SCOPe 2.05: d2a6hm_
Chain 'N':
Compound: DNA-directed RNA polymerase beta' chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE8
Domains in SCOPe 2.05: d2a6hn_
Chain 'O':
Compound: RNA polymerase omega chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE7
Domains in SCOPe 2.05: d2a6ho_
Chain 'P':
Compound: RNA polymerase sigma factor rpoD
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q5SKW1 (Start-422)
Domains in SCOPe 2.05: d2a6hp1, d2a6hp2, d2a6hp3
Heterogens: STD, ZN, MG, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>2a6hA (A:)
mldsklkapvftvrtqgreygefvleplergfgvtlgnplrrillssipgtavtsvyied
vlhefstipgvkedvveiilnlkelvvrflnpslqtvtlllkaegpkevkardflpvadv
eimnpdlhiatleeggrlnmevrvdrgvgyvpaekhgikdrinaipvdavfspvrrvafq
vedtrlgqrtdldkltlriwtdgsvtplealnqaveilrehltyfsnpqaaavaapeeak
epeappeqeeeldlpleelglstrvlhslkeegiesvrallalnlkdlknipgigersle
eikealekkgftlke