SCOPe 2.01: Structural Classification of Proteins

PDB entry 2a68

View 2a68 on RCSB PDB site
Description: Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin
Class: transferase
Keywords: RNA POLYMERASE HOLOENZYME, RIFABUTIN, ANTIBIOTIC, TRANSCRIPTION REGULATION, RIKEN Structural Genomics/Proteomics Initiative, RSGI, Structural Genomics, TRANSFERASE
Deposited on 2005-07-01, released 2005-09-20
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.225
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: DNA-directed RNA polymerase alpha chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Z9H6 (0-End)
Domains in SCOPe 2.01: d2a68a1, d2a68a2
Chain 'B':
Compound: DNA-directed RNA polymerase alpha chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Z9H6 (0-End)
Domains in SCOPe 2.01: d2a68b1, d2a68b2
Chain 'C':
Compound: DNA-directed RNA polymerase beta chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE9 (0-1118)
Domains in SCOPe 2.01: d2a68c_
Chain 'D':
Compound: DNA-directed RNA polymerase beta' chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE8
Domains in SCOPe 2.01: d2a68d1
Chain 'E':
Compound: RNA polymerase omega chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- GB BAB89402
Domains in SCOPe 2.01: d2a68e_
Chain 'F':
Compound: RNA polymerase sigma factor rpoD
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- GB YP_004139 (Start-422)
Domains in SCOPe 2.01: d2a68f1, d2a68f2, d2a68f3
Chain 'K':
Compound: DNA-directed RNA polymerase alpha chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Z9H6 (0-End)
Domains in SCOPe 2.01: d2a68k1, d2a68k2
Chain 'L':
Compound: DNA-directed RNA polymerase alpha chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Z9H6 (0-End)
Domains in SCOPe 2.01: d2a68l1, d2a68l2
Chain 'M':
Compound: DNA-directed RNA polymerase beta chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE9 (0-1118)
Domains in SCOPe 2.01: d2a68m_
Chain 'N':
Compound: DNA-directed RNA polymerase beta' chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE8
Domains in SCOPe 2.01: d2a68n1
Chain 'O':
Compound: RNA polymerase omega chain
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- GB BAB89402
Domains in SCOPe 2.01: d2a68o_
Chain 'P':
Compound: RNA polymerase sigma factor rpoD
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- GB YP_004139 (Start-422)
Domains in SCOPe 2.01: d2a68p1, d2a68p2, d2a68p3
Heterogens: MG, RBT, ZN, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>2a68A (A:)
mldsklkapvftvrtqgreygefvleplergfgvtlgnplrrillssipgtavtsvyied
vlhefstipgvkedvveiilnlkelvvrflnpslqtvtlllkaegpkevkardflpvadv
eimnpdlhiatleeggrlnmevrvdrgvgyvpaekhgikdrinaipvdavfspvrrvafq
vedtrlgqrtdldkltlriwtdgsvtplealnqaveilrehltyfsnpqaaavaapeeak
epeappeqeeeldlpleelglstrvlhslkeegiesvrallalnlkdlknipgigersle
eikealekkgftlke