PDB entry 2a5u

View 2a5u on RCSB PDB site
Description: Crystal Structure of human PI3Kgamma complexed with AS605240
Class: transferase
Keywords: Protein-inhibitor complex, PI3Kg, Transferase
Deposited on 2005-07-01, released 2005-09-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2a5ua1, d2a5ua2, d2a5ua3, d2a5ua4
  • Heterogens: QYT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2a5uA (A:)
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee
wplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvf
veaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapals
skasaespsseskgkvrllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadkl
tsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatd
plnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsal
dvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfll
krglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvieml
qkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekck
vmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldl
cllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfq
aaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginker
vpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpql
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa
hhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2a5uA (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakdfvlrvcgr
deylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeecdrkfrvkirgidip
vlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnl
qiycllyyvnlllidhrfllrrgeyvlhmwqisgfnadkltsatnpdkensmsisilldn
hpiaraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwg
qqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhy
llqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavilea
ylrgcgtamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsql
pesfrvpydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlr
qdmlilqilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgnt
gfkdevlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnl
fhidfghervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsm
mlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvl