PDB entry 2a4z

View 2a4z on RCSB PDB site
Description: Crystal Structure of human PI3Kgamma complexed with AS604850
Class: Transferase
Keywords: Protein-inhibitor complex, PI3Kg, Transferase
Deposited on 2005-06-30, released 2005-09-20
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.264
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2a4za1, d2a4za2, d2a4za3, d2a4za4
  • Heterogens: BYM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2a4zA (A:)
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee
wplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvf
veaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapals
skasaespsseskgkvrllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadkl
tsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatd
plnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsal
dvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfll
krglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvieml
qkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekck
vmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldl
cllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfq
aaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginker
vpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpql
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa
hhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2a4zA (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihsqtikvspddtpgailqsffteqdfvlrvcgrdeylvg
etpiknfqwvrhclkngeeihvvldtppdpaldevrkecdrkfrvkirgidipvlltvfv
eaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycllyyvnll
lidhrfllrrgeyvlhmwqisfnadkltsatnpdkensmsisilldnychpiaraempnq
lrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyql
larrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfe
pyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlh
dftqqvqviemlqkvtldikslvisqlkqklenlqnsqlpesfrvpydpglkagalaiek
ckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesl
dlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteek
fqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfervpfvltpdflfvm
gtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpqltskedieyirdal
tvgkneedakkyfldqievcrdkgwtvqfnwf