PDB entry 2a45

View 2a45 on RCSB PDB site
Description: Crystal structure of the complex between thrombin and the central "E" region of fibrin
Class: hydrolase/hydrolase inhibitor
Keywords: thrombin, fibrin, fragment e, thrombin-fibrin complex, coiled coils, disulfide rings, blood clotting, hydrolase-hydrolase inhibitor complex
Deposited on 2005-06-27, released 2006-05-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-08-14, with a file datestamp of 2019-08-09.
Experiment type: XRAY
Resolution: 3.65 Å
R-factor: N/A
AEROSPACI score: 0.05 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thrombin light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2a45.1
  • Chain 'B':
    Compound: Thrombin heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2a45.1
  • Chain 'D':
    Compound: Thrombin light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2a45.2
  • Chain 'E':
    Compound: Thrombin heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2a45.2
  • Chain 'G':
    Compound: fibrinogen alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2a45g_
  • Chain 'H':
    Compound: fibrinogen beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2a45h_
  • Chain 'I':
    Compound: Fibrinogen gamma chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2a45i_
  • Chain 'J':
    Compound: fibrinogen alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2a45j_
  • Chain 'K':
    Compound: fibrinogen beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2a45k_
  • Chain 'L':
    Compound: Fibrinogen gamma chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2a45l_
  • Heterogens: 0G6, PO4

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2a45A (A:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records): (download) 
    >2a45A (A:)
geadcglrplfekksledkterellesyidgr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2a45B (B:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >2a45B (B:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2a45D (D:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records): (download) 
    >2a45D (D:)
geadcglrplfekksledkterellesyidgr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2a45E (E:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >2a45E (E:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfg

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >2a45G (G:)
gprvverhqsackdsdwpfcsdedwnykcpsgcrmkglidevnqdftnrinklknsl

    Sequence, based on observed residues (ATOM records): (download) 
    >2a45G (G:)
sackdsdwpfcsdedwnykcpsgcrmkglidevnqdftnrinklknsl

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2a45H (H:)
ghrpldkkreeapslrpapppisgggyrarpakaaatqkkverkapdaggclhadpdlgv
lcptgcqlqeallqqerpirnsvdelnnnve

    Sequence, based on observed residues (ATOM records): (download) 
    >2a45H (H:)
kverkapdaggclhadpdlgvlcptgcqlqeallqqerpirnsvdelnnnve

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >2a45I (I:)
yvatrdnccilderfgsycpttcgiadflstyqtkvdkdlqsled

    Sequence, based on observed residues (ATOM records): (download) 
    >2a45I (I:)
dnccilderfgsycpttcgiadflstyqtkvdkdlqsled

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >2a45J (J:)
gprvverhqsackdsdwpfcsdedwnykcpsgcrmkglidevnqdftnrinklknsl

    Sequence, based on observed residues (ATOM records): (download) 
    >2a45J (J:)
sackdsdwpfcsdedwnykcpsgcrmkglidevnqdftnrinklknsl

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >2a45K (K:)
ghrpldkkreeapslrpapppisgggyrarpakaaatqkkverkapdaggclhadpdlgv
lcptgcqlqeallqqerpirnsvdelnnnve

    Sequence, based on observed residues (ATOM records): (download) 
    >2a45K (K:)
kverkapdaggclhadpdlgvlcptgcqlqeallqqerpirnsvdelnnnve

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >2a45L (L:)
yvatrdnccilderfgsycpttcgiadflstyqtkvdkdlqsled

    Sequence, based on observed residues (ATOM records): (download) 
    >2a45L (L:)
vatrdnccilderfgsycpttcgiadflstyqtkvdkdlqsled