PDB entry 2a2q

View 2a2q on RCSB PDB site
Description: Complex of Active-site Inhibited Human Coagulation Factor VIIa with Human Soluble Tissue Factor in the Presence of Ca2+, Mg2+, Na+, and Zn2+
Class: hydrolase/blood clotting
Keywords: Factor VIIa, Soluble Tissue Factor, Mg2+, Ca2+, Na+, Zn2+, HYDROLASE/BLOOD CLOTTING COMPLEX
Deposited on 2005-06-22, released 2006-07-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.198
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2a2qh_
  • Chain 'L':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08709 (0-End)
      • modified residue (5-6)
      • modified residue (13)
      • modified residue (15)
      • modified residue (18-19)
      • modified residue (24-25)
      • modified residue (28)
      • modified residue (34)
    Domains in SCOPe 2.07: d2a2ql1, d2a2ql2, d2a2ql3
  • Chain 'T':
    Compound: tissue factor
    Species: Homo sapiens [TaxId:9606]
    Gene: F3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2a2qt1, d2a2qt2
  • Heterogens: GLC, FUC, MG, CA, NA, ZN, CL, PBZ, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2a2qH (H:)
    ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
    lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
    lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
    sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
    seprpgvllrapfp
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >2a2qL (L:)
    anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
    ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
    ladgvsctptveypcgkipilekrnaskpqgr
    

    Sequence, based on observed residues (ATOM records): (download)
    >2a2qL (L:)
    anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
    ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
    ladgvsctptveypcgkipile
    

  • Chain 'T':
    Sequence, based on SEQRES records: (download)
    >2a2qT (T:)
    tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
    dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgtkvnv
    tvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdkgeny
    cfsvqavipsrtvnrkstdspvecm
    

    Sequence, based on observed residues (ATOM records): (download)
    >2a2qT (T:)
    tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
    dvkqtylarvfsypagngeplyenspeftpyletnlgqptiqsfeqvgtkvnvtvedert
    lvrrnntflslrdvfgkdliytlyywktaktntneflidvdkgenycfsvqavipsrtvn
    rkstdspvecm