PDB entry 2a1a

View 2a1a on RCSB PDB site
Description: PKR kinase domain-eIF2alpha Complex
Class: protein synthesis/transferase
Keywords: transferase, kinase, protein biosynthesis, protein synthesis-transferase COMPLEX
Deposited on 2005-06-19, released 2005-09-27
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.213
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Eukaryotic translation initiation factor 2 alpha subunit
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: SUI2, TIF211
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2a1aa1, d2a1aa2
  • Chain 'B':
    Compound: Interferon-induced, double-stranded RNA-activated protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: PRKR, EIF2AK2, PKR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19525 (3-270)
      • cloning artifact (0-2)
      • engineered (144)
      • modified residue (178)
    Domains in SCOPe 2.05: d2a1ab_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2a1aA (A:)
    gsshcrfyenkypeiddivmvnvqqiaemgayvklleydniegmillselsrrrirsiqk
    lirvgkndvavvlrvdkekgyidlskrrvssediikceekyqksktvhsilrycaekfqi
    pleelyktiawplsrkfghayeafklsiidetvwegieppskdvldelknyiskr
    

    Sequence, based on observed residues (ATOM records): (download)
    >2a1aA (A:)
    shcrfyenkypeiddivmvnvqqiaemgayvklleydniegmillslirvgkndvavvlr
    vdkekgyidlskrrvssediikceekyqksktvhsilrycaekfqipleelyktiawpls
    rkfghayeafklsiidetvwegieppskdvldelknyiskr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2a1aB (B:)
    gahtvdkrfgmdfkeieligsggfgqvfkakhridgktyvikrvkynnekaerevkalak
    ldhvnivhyngcwdgfdydpetssknssrsktkclfiqmefcdkgtleqwiekrrgekld
    kvlalelfeqitkgvdyihskklinrdlkpsniflvdtkqvkigdfglvtslkndgkrtr
    skgtlrymspeqissqdygkevdlyalglilaellhvcdtafetskfftdlrdgiisdif
    dkkektllqkllskkpedrpntseilrtltvwkkspeknerhta
    

    Sequence, based on observed residues (ATOM records): (download)
    >2a1aB (B:)
    gahtvdkrfgmdfkeieligsggfgqvfkakhridgktyvikrvkynnekaerevkalak
    ldhvnivhyngcwdgfdydpetssrsktkclfiqmefcdkgtleqwiekrrgekldkvla
    lelfeqitkgvdyihskklinrdlkpsniflvdtkqvkigdfglvtslkndgkrtrskgt
    lrymspeqissqdygkevdlyalglilaellhvcdtafetskfftdlrdgiisdifdkke
    ktllqkllskkpedrpntseilrtltvwkk