PDB entry 2a0y

View 2a0y on RCSB PDB site
Description: Structure of human purine nucleoside phosphorylase H257D mutant
Class: transferase
Keywords: purine nucleoside phosphorylase, transition state inhibitor, mutant, TRANSFERASE
Deposited on 2005-06-17, released 2006-06-06
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: 0.243
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: purine nucleoside phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: NP, PNP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00491
      • engineered (256)
    Domains in SCOPe 2.01: d2a0ya_
  • Heterogens: SO4, DIH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2a0yA (A:)
mengytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprst
vpghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaaggl
npkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkq
mgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfsl
itnkvimdyeslekandeevlaagkqaaqkleqfvsilmasiplpdkas

    Sequence, based on observed residues (ATOM records): (download) 
    >2a0yA (A:)
ngytyedykntaewllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprstvp
ghagrlvfgflngracvmmqgrfhmyegyplwkvtfpvrvfhllgvdtlvvtnaagglnp
kfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstwkqmg
eqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfslit
nkvimdyeslekandeevlaagkqaaqkleqfvsilmasipl