PDB entry 1zy4

View 1zy4 on RCSB PDB site
Description: Crystal Structure of eIF2alpha Protein Kinase GCN2: R794G Hyperactivating Mutant in Apo Form.
Class: transferase
Keywords: translation regulator, protein kinase, signal transduction, amino-acid starvation, starvation stress response, eif2alpha kinase, transferase
Deposited on 2005-06-09, released 2005-06-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-02-03, with a file datestamp of 2021-01-29.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase GCN2
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: GCN2, AAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15442 (2-72)
      • cloning artifact (0-1)
      • engineered (99)
    • Uniprot P15442 (73-End)
    Domains in SCOPe 2.08: d1zy4a1, d1zy4a2
  • Chain 'B':
    Compound: Serine/threonine-protein kinase GCN2
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: GCN2, AAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15442 (2-72)
      • cloning artifact (0-1)
      • engineered (99)
    • Uniprot P15442 (73-End)
    Domains in SCOPe 2.08: d1zy4b1, d1zy4b2
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1zy4A (A:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnfvkpmtavkkkstlfiqmeycengtlydlihsenlnqqrdeywr
lfrqilealsyihsqgiihrdlkpmnifidesrnvkigdfglaknvhrsldilkldsqnl
pgssdnltsaigtamyvatevldgtghynekidmyslgiiffemiypfstgmervnilkk
lrsvsiefppdfddnkmkvekkiirllidhdpnkrpgartllnsgwlpvkhqdevikeal
ksl

    Sequence, based on observed residues (ATOM records): (download) 
    >1zy4A (A:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnfvkkkstlfiqmeycengtlydlihsenlnqqrdeywrlfrqil
ealsyihsqgiihrdlkpmnifidesrnvkigdfglaknvhramyvatevldgtghynek
idmyslgiiffemiypfstgmervnilkklrsvsiefppdfddnkmkvekkiirllidhd
pnkrpgartllnsgwlpvkhqdevikealks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1zy4B (B:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnfvkpmtavkkkstlfiqmeycengtlydlihsenlnqqrdeywr
lfrqilealsyihsqgiihrdlkpmnifidesrnvkigdfglaknvhrsldilkldsqnl
pgssdnltsaigtamyvatevldgtghynekidmyslgiiffemiypfstgmervnilkk
lrsvsiefppdfddnkmkvekkiirllidhdpnkrpgartllnsgwlpvkhqdevikeal
ksl

    Sequence, based on observed residues (ATOM records): (download) 
    >1zy4B (B:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnfvkkstlfiqmeycengtlydlihsenlnqqrdeywrlfrqile
alsyihsqgiihrdlkpmnifidesrnvkigdfgligtamyvatevlynekidmyslgii
ffemiypfstgmervnilkklrsvsiefppdfddnkmkvekkiirllidhdpnkrpgart
llnsgwlpv