PDB entry 1zxe

View 1zxe on RCSB PDB site
Description: Crystal Structure of eIF2alpha Protein Kinase GCN2: D835N Inactivating Mutant in Apo Form
Class: transferase
Keywords: Translation regulator, Protein kinase, Signal transduction, Amino-acid starvation, Starvation stress response, eIF2alpha kinase, TRANSFERASE
Deposited on 2005-06-07, released 2005-06-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-02-03, with a file datestamp of 2021-01-29.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: GCN2, AAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15442 (2-72)
      • cloning artifact (0-1)
      • modified residue (53)
      • modified residue (93)
      • engineered (140)
      • modified residue (144)
      • modified residue (194)
      • modified residue (213)
      • modified residue (223)
      • modified residue (231)
      • modified residue (256)
    • Uniprot P15442 (73-End)
    Domains in SCOPe 2.08: d1zxea1, d1zxea2
  • Chain 'B':
    Compound: Serine/threonine-protein kinase
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: GCN2, AAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15442 (2-72)
      • cloning artifact (0-1)
      • modified residue (53)
      • modified residue (93)
      • engineered (140)
      • modified residue (144)
      • modified residue (194)
      • modified residue (213)
      • modified residue (223)
      • modified residue (231)
      • modified residue (256)
    • Uniprot P15442 (73-End)
    Domains in SCOPe 2.08: d1zxeb1, d1zxeb2
  • Chain 'C':
    Compound: Serine/threonine-protein kinase
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: GCN2, AAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15442 (2-72)
      • cloning artifact (0-1)
      • modified residue (53)
      • modified residue (93)
      • engineered (140)
      • modified residue (144)
      • modified residue (194)
      • modified residue (213)
      • modified residue (223)
      • modified residue (231)
      • modified residue (256)
    • Uniprot P15442 (73-End)
    Domains in SCOPe 2.08: d1zxec1, d1zxec2
  • Chain 'D':
    Compound: Serine/threonine-protein kinase
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: GCN2, AAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15442 (2-72)
      • cloning artifact (0-1)
      • modified residue (53)
      • modified residue (93)
      • engineered (140)
      • modified residue (144)
      • modified residue (194)
      • modified residue (213)
      • modified residue (223)
      • modified residue (231)
      • modified residue (256)
    • Uniprot P15442 (73-End)
    Domains in SCOPe 2.08: d1zxed1, d1zxed2
  • Chain 'E':
    Compound: Serine/threonine-protein kinase
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: GCN2, AAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15442 (2-72)
      • cloning artifact (0-1)
      • modified residue (53)
      • modified residue (93)
      • engineered (140)
      • modified residue (144)
      • modified residue (194)
      • modified residue (213)
      • modified residue (223)
      • modified residue (231)
      • modified residue (256)
    • Uniprot P15442 (73-End)
    Domains in SCOPe 2.08: d1zxee1, d1zxee2
  • Chain 'F':
    Compound: Serine/threonine-protein kinase
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: GCN2, AAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15442 (2-72)
      • cloning artifact (0-1)
      • modified residue (53)
      • modified residue (93)
      • engineered (140)
      • modified residue (144)
      • modified residue (194)
      • modified residue (213)
      • modified residue (223)
      • modified residue (231)
      • modified residue (256)
    • Uniprot P15442 (73-End)
    Domains in SCOPe 2.08: d1zxef1, d1zxef2
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1zxeA (A:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnfvkpmtavkkkstlfiqmeycenrtlydlihsenlnqqrdeywr
lfrqilealsyihsqgiihrnlkpmnifidesrnvkigdfglaknvhrsldilkldsqnl
pgssdnltsaigtamyvatevldgtghynekidmyslgiiffemiypfstgmervnilkk
lrsvsiefppdfddnkmkvekkiirllidhdpnkrpgartllnsgwlpvkhqdevikeal
ksl

    Sequence, based on observed residues (ATOM records): (download) 
    >1zxeA (A:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnfvkkkstlfiqmeycenrtlydlihsenlnqqrdeywrlfrqil
ealsyihsqgiihrnlkpmnifidesrnvkigdfglaknaigtamyvatevldghyneki
dmyslgiiffemiypfstgmervnilkklrsvsiefppdfddnkmkvekkiirllidhdp
nkrpgartllnsgwlpvkhqdevikealk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1zxeB (B:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnfvkpmtavkkkstlfiqmeycenrtlydlihsenlnqqrdeywr
lfrqilealsyihsqgiihrnlkpmnifidesrnvkigdfglaknvhrsldilkldsqnl
pgssdnltsaigtamyvatevldgtghynekidmyslgiiffemiypfstgmervnilkk
lrsvsiefppdfddnkmkvekkiirllidhdpnkrpgartllnsgwlpvkhqdevikeal
ksl

    Sequence, based on observed residues (ATOM records): (download) 
    >1zxeB (B:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnkstlfiqmeycenrtlydlihsenlnqqrdeywrlfrqileals
yihsqgiihrnlkpmnifidesrnvkigdfglaknvgtamyvatevlghynekidmyslg
iiffemiypfstgmervnilkklrsvsiefppdfddnkmkvekkiirllidhdpnkrpga
rtllnsgwlpvk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1zxeC (C:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnfvkpmtavkkkstlfiqmeycenrtlydlihsenlnqqrdeywr
lfrqilealsyihsqgiihrnlkpmnifidesrnvkigdfglaknvhrsldilkldsqnl
pgssdnltsaigtamyvatevldgtghynekidmyslgiiffemiypfstgmervnilkk
lrsvsiefppdfddnkmkvekkiirllidhdpnkrpgartllnsgwlpvkhqdevikeal
ksl

    Sequence, based on observed residues (ATOM records): (download) 
    >1zxeC (C:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnfvkkkstlfiqmeycenrtlydlihsenlnqqrdeywrlfrqil
ealsyihsqgiihrnlkpmnifidesrnvkigdfglaknvtsaigtamyvatevldgtgh
ynekidmyslgiiffemiypfstgmervnilkklrsvsiefppdfddnkmkvekkiirll
idhdpnkrpgartllnsgwlpvkhqdevikealks

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1zxeD (D:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnfvkpmtavkkkstlfiqmeycenrtlydlihsenlnqqrdeywr
lfrqilealsyihsqgiihrnlkpmnifidesrnvkigdfglaknvhrsldilkldsqnl
pgssdnltsaigtamyvatevldgtghynekidmyslgiiffemiypfstgmervnilkk
lrsvsiefppdfddnkmkvekkiirllidhdpnkrpgartllnsgwlpvkhqdevikeal
ksl

    Sequence, based on observed residues (ATOM records): (download) 
    >1zxeD (D:)
slryasdfeeiavlgqgqvvkarnaldsryyaikkirhteeklstilsevmllaslnhqy
vvryyaawlerrnfvkkstlfiqmeycenrtlydlihsenlnqqrdeywrlfrqileals
yihsqgiihrnlkpmnifidesrnvkigdfglaknvhgtamyvatevldgtghynekidm
yslgiiffemiypfstgmervnilkklrsvsiefppdfddnkmkvekkiirllidhdpnk
rpgartllnsgwlpvk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1zxeE (E:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnfvkpmtavkkkstlfiqmeycenrtlydlihsenlnqqrdeywr
lfrqilealsyihsqgiihrnlkpmnifidesrnvkigdfglaknvhrsldilkldsqnl
pgssdnltsaigtamyvatevldgtghynekidmyslgiiffemiypfstgmervnilkk
lrsvsiefppdfddnkmkvekkiirllidhdpnkrpgartllnsgwlpvkhqdevikeal
ksl

    Sequence, based on observed residues (ATOM records): (download) 
    >1zxeE (E:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnkkstlfiqmeycenrtlydlihsenlnqqrdeywrlfrqileal
syihsqgiihrnlkpmnifidesrnvkigdfglaknvgtamyvatevlghynekidmysl
giiffemiypfstgmervnilkklrsvsiefppdfddnkmkvekkiirllidhdpnkrpg
artllnsgwlpvkhqdevikealk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1zxeF (F:)
slryasdfeeiavlgqgafgqvvkarnaldsryyaikkirhteeklstilsevmllasln
hqyvvryyaawlerrnfvkpmtavkkkstlfiqmeycenrtlydlihsenlnqqrdeywr
lfrqilealsyihsqgiihrnlkpmnifidesrnvkigdfglaknvhrsldilkldsqnl
pgssdnltsaigtamyvatevldgtghynekidmyslgiiffemiypfstgmervnilkk
lrsvsiefppdfddnkmkvekkiirllidhdpnkrpgartllnsgwlpvkhqdevikeal
ksl

    Sequence, based on observed residues (ATOM records): (download) 
    >1zxeF (F:)
slryasdfeeiavlgqfgqvvkarnaldsryyaikkirhteeklstilsevmllaslnhq
yvvryyaawlerrnkstlfiqmeycenrtlydlihsenlnqqrdeywrlfrqilealsyi
hsqgiihrnlkpmnifidesrnvkigdfglaknigtamyvatevldynekidmyslgiif
femiypfstgmervnilkklrsvsiefppdfddnkmkvekkiirllidhdpnkrpgartl
lnsgwlpvk