PDB entry 1zxc
View 1zxc on RCSB PDB site
Description: Crystal structure of catalytic domain of TNF-alpha converting enzyme (TACE) with inhibitor
Class: hydrolase
Keywords: TACE/ADAM-17, TACE-Inhibitor complex, Zn-endopeptidase
Deposited on
2005-06-07, released
2005-09-27
The last revision prior to the SCOP 1.73 freeze date was dated
2005-09-27, with a file datestamp of
2007-06-04.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: 0.216
AEROSPACI score: 0.34
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: adam 17
Species: HOMO SAPIENS
Gene: ADAM17, CSVP, TACE
Database cross-references and differences (RAF-indexed):
- Uniprot P78536
- engineered (51)
- engineered (237)
Domains in SCOP 1.73: d1zxca1 - Chain 'B':
Compound: adam 17
Species: HOMO SAPIENS
Gene: ADAM17, CSVP, TACE
Database cross-references and differences (RAF-indexed):
- Uniprot P78536
- engineered (51)
- engineered (237)
Domains in SCOP 1.73: d1zxcb1 - Heterogens: ZN, IH6, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1zxcA (A:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersnkv
Sequence, based on observed residues (ATOM records): (download)
>1zxcA (A:)
dpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgyg
iqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclah
lftyqdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknygktilt
keadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskq
siyktieskaqecfqersn
- Chain 'B':
Sequence, based on SEQRES records: (download)
>1zxcB (B:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersnkv
Sequence, based on observed residues (ATOM records): (download)
>1zxcB (B:)
pdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgygi
qieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclahl
ftyqdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknygktiltk
eadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskqs
iyktieskaqecfqersn