PDB entry 1zgl

View 1zgl on RCSB PDB site
Description: Crystal structure of 3A6 TCR bound to MBP/HLA-DR2a
Class: immune system
Keywords: TCR/peptide/MHC complex, IMMUNE SYSTEM
Deposited on 2005-04-21, released 2005-10-18
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.28
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1zgla1, d1zgla2
  • Chain 'B':
    Compound: major histocompatibility complex, class II, DR beta 5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1zglb1, d1zglb2
  • Chain 'C':
    Compound: myelin basic protein
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6AI64 (0-12)
      • cloning artifact (13)
  • Chain 'D':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1zgld1, d1zgld2
  • Chain 'E':
    Compound: major histocompatibility complex, class II, DR beta 5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1zgle1, d1zgle2
  • Chain 'F':
    Compound: myelin basic protein
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6AI64 (0-12)
      • cloning artifact (13-14)
  • Chain 'G':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1zglg1, d1zglg2
  • Chain 'H':
    Compound: major histocompatibility complex, class II, DR beta 5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1zglh1, d1zglh2
  • Chain 'I':
    Compound: myelin basic protein
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6AI64 (Start-12)
      • cloning artifact (13)
  • Chain 'J':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1zglj1, d1zglj2
  • Chain 'K':
    Compound: major histocompatibility complex, class II, DR beta 5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1zglk1, d1zglk2
  • Chain 'L':
    Compound: myelin basic protein
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6AI64 (0-12)
      • cloning artifact (13)
  • Chain 'M':
    Compound: T cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'P':
    Compound: T cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1zglp1, d1zglp2
  • Chain 'Q':
    Compound: T cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: T cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1zglr1, d1zglr2
  • Chain 'S':
    Compound: T cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'T':
    Compound: T cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1zglt1, d1zglt2
  • Chain 'U':
    Compound: T cell receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'V':
    Compound: T cell receptor beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1zglv1, d1zglv2

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1zglA (A:)
    ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
    aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
    wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
    d
    

    Sequence, based on observed residues (ATOM records): (download)
    >1zglA (A:)
    ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
    avdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwlr
    ngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1zglB (B:)
    gdtrprflqqdkyechffngtervrflhrdiynqeedlrfdsdvgeyravtelgrpdaey
    wnsqkdfledrraavdtycrhnygvgesftvqrrvepkvtvypartqtlqhhnllvcsvn
    gfypgsievrwfrnsqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
    tspltvewraqs
    

    Sequence, based on observed residues (ATOM records): (download)
    >1zglB (B:)
    gdtrprflqqdkyechffngtervrflhrdiynqeedlrfdsdvgeyravtelgrpdaey
    wnsqkdfledrraavdtycrhnygvgesftvqrrvepkvtvyprtnllvcsvngfypgsi
    evrwfnsvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvtspltvewr
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1zglD (D:)
    ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
    aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
    wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
    d
    

    Sequence, based on observed residues (ATOM records): (download)
    >1zglD (D:)
    ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
    avdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwlr
    ngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >1zglE (E:)
    gdtrprflqqdkyechffngtervrflhrdiynqeedlrfdsdvgeyravtelgrpdaey
    wnsqkdfledrraavdtycrhnygvgesftvqrrvepkvtvypartqtlqhhnllvcsvn
    gfypgsievrwfrnsqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
    tspltvewraqs
    

    Sequence, based on observed residues (ATOM records): (download)
    >1zglE (E:)
    dtrprflqqdkyechffngtervrflhrdiynqeedlrfdsdvgeyravtelgrpdaeyw
    nsqkdfledrraavdtycrhnygvgesftvqrrvepkvtvyprtnllvcsvngfypgsie
    vrwfrnsqevvstgliqngdwtfqtlvmleprsgevytcqvehpsvtspltvewr
    

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >1zglG (G:)
    ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
    aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
    wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
    d
    

    Sequence, based on observed residues (ATOM records): (download)
    >1zglG (G:)
    ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
    avdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwlr
    ngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >1zglH (H:)
    gdtrprflqqdkyechffngtervrflhrdiynqeedlrfdsdvgeyravtelgrpdaey
    wnsqkdfledrraavdtycrhnygvgesftvqrrvepkvtvypartqtlqhhnllvcsvn
    gfypgsievrwfrnsqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
    tspltvewraqs
    

    Sequence, based on observed residues (ATOM records): (download)
    >1zglH (H:)
    gdtrprflqqdkyechffngtervrflhrdiynqeedlrfdsdvgeyravtelgrpdaey
    wnsqkdfledrraavdtycrhnygvgesftvqrrvepkvtvypanllvcsvngfypgsie
    vrwfvvstgliqngdwtfqtlvmlesgevytcqvehpsvtspltvewr
    

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    Sequence, based on SEQRES records: (download)
    >1zglJ (J:)
    ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
    aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
    wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
    d
    

    Sequence, based on observed residues (ATOM records): (download)
    >1zglJ (J:)
    ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
    avdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwlr
    ngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd
    

  • Chain 'K':
    Sequence, based on SEQRES records: (download)
    >1zglK (K:)
    gdtrprflqqdkyechffngtervrflhrdiynqeedlrfdsdvgeyravtelgrpdaey
    wnsqkdfledrraavdtycrhnygvgesftvqrrvepkvtvypartqtlqhhnllvcsvn
    gfypgsievrwfrnsqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
    tspltvewraqs
    

    Sequence, based on observed residues (ATOM records): (download)
    >1zglK (K:)
    gdtrprflqqdkyechffngtervrflhrdiynqeedlrfdsdvgeyravtelgrpdaey
    wnsqkdfledrraavdtycrhnygvgesftvqrrvepkvtvypnllvcsvngfypgsiev
    rwfrnsqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvtspltvewr
    

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    No sequence available.

  • Chain 'P':
    Sequence, based on SEQRES records: (download)
    >1zglP (P:)
    gggggvtqtpryliktrgqqvtlscspisghrsvswyqqtpgqglqflfeyfnetqrnkg
    nfpgrfsgrqfsnsrsemnvstlelgdsalylcassladrvnteaffgqgtrltvvedlk
    nvfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplk
    eqpalndsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsae
    awgradcaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >1zglP (P:)
    gggggvtqtpryliktrgqqvtlscspisghrsvswyqqtpgqglqflfeyfnetqrnkg
    nfpgrfsgrqfsnsrsemnvstlelgdsalylcassladrvnteaffgqgtrltvvedlk
    nvfppevavfepseaeishtqatlvclatgfypdhvelswwvngkevhsgvstdpqplke
    qpalndsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
    wg
    

  • Chain 'Q':
    No sequence available.

  • Chain 'R':
    Sequence, based on SEQRES records: (download)
    >1zglR (R:)
    gggggvtqtpryliktrgqqvtlscspisghrsvswyqqtpgqglqflfeyfnetqrnkg
    nfpgrfsgrqfsnsrsemnvstlelgdsalylcassladrvnteaffgqgtrltvvedlk
    nvfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplk
    eqpalndsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsae
    awgradcaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >1zglR (R:)
    ggggvtqtpryliktrgqqvtlscspisghrsvswyqqtpgqglqflfeyfnetqrnkgn
    fpgrfsgrqfsnsrsemnvstlelgdsalylcassladrvnteaffgqgtrltvvedlkn
    vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplke
    qpalndsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsa
    

  • Chain 'S':
    No sequence available.

  • Chain 'T':
    Sequence, based on SEQRES records: (download)
    >1zglT (T:)
    gggggvtqtpryliktrgqqvtlscspisghrsvswyqqtpgqglqflfeyfnetqrnkg
    nfpgrfsgrqfsnsrsemnvstlelgdsalylcassladrvnteaffgqgtrltvvedlk
    nvfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplk
    eqpalndsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsae
    awgradcaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >1zglT (T:)
    gggggvtqtpryliktrgqqvtlscspisghrsvswyqqtpgqglqflfeyfnetqrnkg
    nfpgrfsgrqfsnsrsemnvstlelgdsalylcassladrvnteaffgqgtrltvvedlk
    nvfppevvfeishtqatlvclatgfypdhvelswwvnvhsgvstdpqplkeqpalndsry
    slssratwqnprhfrcqvqfyglsendewtqdrakpvtqivswgad
    

  • Chain 'U':
    No sequence available.

  • Chain 'V':
    Sequence, based on SEQRES records: (download)
    >1zglV (V:)
    gggggvtqtpryliktrgqqvtlscspisghrsvswyqqtpgqglqflfeyfnetqrnkg
    nfpgrfsgrqfsnsrsemnvstlelgdsalylcassladrvnteaffgqgtrltvvedlk
    nvfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplk
    eqpalndsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsae
    awgradcaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >1zglV (V:)
    ggggvtqtpryliktrgqqvtlscspisghrsvswyqqtpgqglqflfeyfnetqrnkgn
    fpgrfsgrqfsnsrsemnvstlelgdsalylcassladrvnteaffgqgtrltvvedlkn
    vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplke
    qpalndsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
    wg