PDB entry 1z89

View 1z89 on RCSB PDB site
Description: Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor
Class: oxidoreductase
Keywords: Sulfonyl-pyridazinone, TIM-barrel
Deposited on 2005-03-30, released 2006-03-14
The last revision prior to the SCOP 1.73 freeze date was dated 2006-03-14, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.43 Å
R-factor: 0.163
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aldose reductase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • GB AAA51714 (0-315)
    Domains in SCOP 1.73: d1z89a1
  • Heterogens: NAP, 62P, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1z89A (A:)
    masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
    eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
    effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
    avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
    hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
    llsctshkdypfheef