PDB entry 1z6j

View 1z6j on RCSB PDB site
Description: Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor
Class: hydrolase
Keywords: Blood coagulation, serine protease, thrombosis, gla, pyrazinone, benzamidine, tissue factor, cofactor, enzyme inhibitor complex
Deposited on 2005-03-22, released 2005-05-03
The last revision prior to the SCOP 1.73 freeze date was dated 2005-06-14, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.209
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII
    Species: HOMO SAPIENS
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1z6jh1
  • Chain 'L':
    Compound: Coagulation factor VII
    Species: HOMO SAPIENS
    Gene: F7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08709 (0-141)
      • modified residue (5-6)
      • modified residue (13)
      • modified residue (15)
      • modified residue (18-19)
      • modified residue (24-25)
      • modified residue (28)
      • modified residue (34)
    Domains in SCOP 1.73: d1z6jl1, d1z6jl2, d1z6jl3
  • Chain 'T':
    Compound: tissue factor
    Species: HOMO SAPIENS
    Gene: F3
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1z6jt1, d1z6jt2
  • Heterogens: CA, MG, PY3, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1z6jH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1z6jL (L:)
anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
ladgvsctptveypcgkipile

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >1z6jT (T:)
sgttntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdlt
deivkdvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvg
tkvnvtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvd
kgenycfsvqavipsrtvnrkstdspvecmg

    Sequence, based on observed residues (ATOM records): (download) 
    >1z6jT (T:)
sgttntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdlt
deivkdvkqtylarvfsypagnvesteplyenspeftpyletnlgqptiqsfeqvgtkvn
vtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdkgen
ycfsvqavipsrtvnrkstdspvecmg