PDB entry 1z6e

View 1z6e on RCSB PDB site
Description: Factor XA in complex with the inhibitor 1-(3'-amino-1,2-benzisoxazol-5'-yl)-n-(4-(2'-((dimethylamino)methyl)-1h-imidazol-1-yl)-2-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (razaxaban; DPC906; BMS-561389)
Class: hydrolase
Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, blood coagulation, cleavage on pair of basic residues, disulfide bond, egf-like domain
Deposited on 2005-03-22, released 2006-03-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.221
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: coagulation factor x
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00742 (0-233)
  Domains in SCOPe 2.07: d1z6ea_
• Chain 'L':
  Compound: coagulation factor x
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00742 (0-51)
  Domains in SCOPe 2.07: d1z6el_
• Heterogens: IK8, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1z6eA (A:)
  ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
  qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
  tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
  cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt
  

  
  
• Chain 'L':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1z6eL (L:)
  klcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtle