PDB entry 1z3n

View 1z3n on RCSB PDB site
Description: Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom
Class: oxidoreductase
Keywords: oxidoreductase, nadp+, lidorestat
Deposited on 2005-03-14, released 2006-03-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.04 Å
R-factor: 0.098
AEROSPACI score: 1.03 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aldose reductase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB AAA51714 (3-318)
    Domains in SCOPe 2.07: d1z3na_
  • Heterogens: NDP, 3NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1z3nA (A:)
    gshmasrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgv
    aiqeklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfk
    pgkeffpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglk
    ykpavnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikai
    aakhnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwr
    vcallsctshkdypfheef
    

    Sequence, based on observed residues (ATOM records): (download)
    >1z3nA (A:)
    masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
    eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
    effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
    avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
    hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
    llsctshkdypfheef