PDB entry 1yy9
View 1yy9 on RCSB PDB site
Description: Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225
Class: IMMUNE SYSTEM/Transferase
Keywords: CELL SURFACE RECEPTOR; TYROSINE KINASE; GLYCOPROTEIN; ANTIGEN:ANTIBODY COMPLEX; FAB FRAGMENT; ANTITUMOR; DRUG, IMMUNE SYSTEM-Transferase complex
Deposited on
2005-02-24, released
2005-04-26
The last revision prior to the SCOPe 2.01 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-25.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.242
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB1
Database cross-references and differences (RAF-indexed):
- Uniprot P00533
- conflict (473)
- conflict (609)
Domains in SCOPe 2.01: d1yy9a1, d1yy9a2, d1yy9a3, d1yy9a4 - Chain 'C':
Compound: Cetuximab Fab Light chain
Species: Mus musculus, Homo sapiens [TaxId:10090,9606]
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: Cetuximab Fab Heavy chain
Species: Mus musculus, Homo sapiens [TaxId:10090,9606]
Database cross-references and differences (RAF-indexed):
- Heterogens: NDG, NAG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1yy9A (A:)
leekkvcqgtsnkltqlgtfedhflslqrmfnncevvlgnleityvqrnydlsflktiqe
vagyvlialntveriplenlqiirgnmyyensyalavlsnydanktglkelpmrnlqeil
hgavrfsnnpalcnvesiqwrdivssdflsnmsmdfqnhlgscqkcdpscpngscwgage
encqkltkiicaqqcsgrcrgkspsdcchnqcaagctgpresdclvcrkfrdeatckdtc
pplmlynpttyqmdvnpegkysfgatcvkkcprnyvvtdhgscvracgadsyemeedgvr
kckkcegpcrkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsftht
ppldpqeldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvsln
itslglrslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgenkckatgq
vchalcspegcwgpeprdcvscrnvsrgrecvdkckllegeprefvenseciqchpeclp
qamnitctgrgpdnciqcahyidgphcvktcpagvmgenntlvwkyadaghvchlchpnc
tygctgpglrgcptngpkhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>1yy9A (A:)
eekkvcqgtsnkltqlgtfedhflslqrmfnncevvlgnleityvqrnydlsflktiqev
agyvlialntveriplenlqiirgnmyyensyalavlsnydanktglkelpmrnlqeilh
gavrfsnnpalcnvesiqwrdivssdflsnmsmdfqnhlgscqkcdpscpngscwgagee
ncqkltkiicaqqcsgrcrgkspsdcchnqcaagctgpresdclvcrkfrdeatckdtcp
plmlynpttyqmdvnpegkysfgatcvkkcprnyvvtdhgscvracgadsyemeedgvrk
ckkcegpcrkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtp
pldpqeldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslni
tslglrslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgenkckatgqv
chalcspegcwgpeprdcvscrnvsrgrecvdkckllegeprefvenseciqchpeclpq
amnitctgrgpdnciqcahyidgphcvktcpagvmgenntlvwkyadaghvchlchpnct
ygctgpglrgcpt
- Chain 'C':
No sequence available.
- Chain 'D':
No sequence available.