PDB entry 1yy9

View 1yy9 on RCSB PDB site
Description: Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225
Class: immune system/siganling protein
Keywords: cell surface receptor; tyrosine kinase; glycoprotein; antigen:antibody complex; fab fragment; antitumor; drug
Deposited on 2005-02-24, released 2005-04-26
The last revision prior to the SCOP 1.73 freeze date was dated 2005-04-26, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.242
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: HOMO SAPIENS
    Gene: EGFR
    Database cross-references and differences (RAF-indexed):
    • GB CAA25240
      • conflict (473)
      • conflict (609)
    Domains in SCOP 1.73: d1yy9a1, d1yy9a2, d1yy9a3, d1yy9a4
  • Chain 'C':
    Compound: Cetuximab Fab Light chain
    Species: Mus musculus/Homo sapiens
  • Chain 'D':
    Compound: Cetuximab Fab Heavy chain
    Species: Mus musculus/Homo sapiens
  • Heterogens: NDG, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1yy9A (A:)
    leekkvcqgtsnkltqlgtfedhflslqrmfnncevvlgnleityvqrnydlsflktiqe
    vagyvlialntveriplenlqiirgnmyyensyalavlsnydanktglkelpmrnlqeil
    hgavrfsnnpalcnvesiqwrdivssdflsnmsmdfqnhlgscqkcdpscpngscwgage
    encqkltkiicaqqcsgrcrgkspsdcchnqcaagctgpresdclvcrkfrdeatckdtc
    pplmlynpttyqmdvnpegkysfgatcvkkcprnyvvtdhgscvracgadsyemeedgvr
    kckkcegpcrkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsftht
    ppldpqeldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvsln
    itslglrslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgenkckatgq
    vchalcspegcwgpeprdcvscrnvsrgrecvdkckllegeprefvenseciqchpeclp
    qamnitctgrgpdnciqcahyidgphcvktcpagvmgenntlvwkyadaghvchlchpnc
    tygctgpglrgcptngpkhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >1yy9A (A:)
    eekkvcqgtsnkltqlgtfedhflslqrmfnncevvlgnleityvqrnydlsflktiqev
    agyvlialntveriplenlqiirgnmyyensyalavlsnydanktglkelpmrnlqeilh
    gavrfsnnpalcnvesiqwrdivssdflsnmsmdfqnhlgscqkcdpscpngscwgagee
    ncqkltkiicaqqcsgrcrgkspsdcchnqcaagctgpresdclvcrkfrdeatckdtcp
    plmlynpttyqmdvnpegkysfgatcvkkcprnyvvtdhgscvracgadsyemeedgvrk
    ckkcegpcrkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtp
    pldpqeldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslni
    tslglrslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgenkckatgqv
    chalcspegcwgpeprdcvscrnvsrgrecvdkckllegeprefvenseciqchpeclpq
    amnitctgrgpdnciqcahyidgphcvktcpagvmgenntlvwkyadaghvchlchpnct
    ygctgpglrgcpt
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.