PDB entry 1yy8

View 1yy8 on RCSB PDB site
Description: Crystal structure of the Fab fragment from the monoclonal antibody cetuximab/Erbitux/IMC-C225
Deposited on 2005-02-24, released 2005-04-26
The last revision was dated 2009-02-24, with a file datestamp of 2009-02-19.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.224
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cetuximab Fab Light chain
    Species: , [TaxId:10090,9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1YY8 (0-212)
  • Chain 'B':
    Compound: Cetuximab Fab Heavy chain
    Species: , [TaxId:10090,9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1YY8 (0-220)
  • Chain 'C':
    Compound: Cetuximab Fab Light chain
    Species: , [TaxId:10090,9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1YY8 (0-212)
  • Chain 'D':
    Compound: Cetuximab Fab Heavy chain
    Species: , [TaxId:10090,9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1YY8 (0-220)
  • Heterogens: HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.07, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records:
    >1yy8A (A:)
    dilltqspvilsvspgervsfscrasqsigtnihwyqqrtngsprllikyasesisgips
    rfsgsgsgtdftlsinsvesediadyycqqnnnwpttfgagtklelkrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrga
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >1yy8B (B:)
    qvqlkqsgpglvqpsqslsitctvsgfsltnygvhwvrqspgkglewlgviwsggntdyn
    tpftsrlsinkdnsksqvffkmnslqsndtaiyycaraltyydyefaywgqgtlvtvsaa
    stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
    lyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepks
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >1yy8C (C:)
    dilltqspvilsvspgervsfscrasqsigtnihwyqqrtngsprllikyasesisgips
    rfsgsgsgtdftlsinsvesediadyycqqnnnwpttfgagtklelkrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrga
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >1yy8D (D:)
    qvqlkqsgpglvqpsqslsitctvsgfsltnygvhwvrqspgkglewlgviwsggntdyn
    tpftsrlsinkdnsksqvffkmnslqsndtaiyycaraltyydyefaywgqgtlvtvsaa
    stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
    lyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepks