PDB entry 1ypv

View 1ypv on RCSB PDB site
Description: Structure of human thymidylate synthase at low salt conditions
Class: transferase
Keywords: thymidylate synthase, methyltransferase, transferase
Deposited on 2005-01-31, released 2005-04-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.227
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • modified residue (42)
      • modified residue (179)
      • modified residue (194)
      • modified residue (198)
    Domains in SCOPe 2.07: d1ypva1
  • Heterogens: PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1ypvA (A:)
    mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfg
    mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
    lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimc
    awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
    tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
    ynphptikmemav
    

    Sequence, based on observed residues (ATOM records): (download)
    >1ypvA (A:)
    vpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgv
    leellwfikgstnakelsskgvkdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvid
    tiktnpddrriimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfn
    iasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkve
    kiddfkaedfqiegynphptikme