PDB entry 1yov

View 1yov on RCSB PDB site
Description: Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8
Class: signaling protein
Keywords: ubiquitin, NEDD8, E1, APPBP1, UBA3, SIGNALING PROTEIN
Deposited on 2005-01-28, released 2005-03-08
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.236
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: amyloid protein-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: APPBP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1yova_
  • Chain 'B':
    Compound: ubiquitin-activating enzyme E1C
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE1C, UBA3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1yovb_
  • Chain 'C':
    Compound: amyloid protein-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: APPBP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1yovc_
  • Chain 'D':
    Compound: ubiquitin-activating enzyme E1C
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE1C, UBA3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1yovd_
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1yovA (A:)
mklmaqlgkllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsf
tiidgnqvsgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndp
sffcrftvvvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpd
naledlrldkpfpelrehfqsydldhmekkdhshtpwiviiakylaqwysetngripkty
kekedfrdlirqgilknengapedeenfeeaiknvntalnttqipssiedifnddrcini
tkqtpsfwilaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaav
gnhvakllqsigqapesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmd
npdneivlylmlravdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkdd
yvhefcrygaaephtiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

    Sequence, based on observed residues (ATOM records): (download) 
    >1yovA (A:)
kllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftiidgnqv
sgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsffcrftv
vvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnaledlrl
dkpfpelrehfqsydldhmekkdhshtpwiviiakylaqwysetngripktykekedfrd
lirqgilknengapedeenfeeaiknvntalnttqipssiedifnddrcinitkqtpsfw
ilaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakll
qsigqapesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivl
ylmlravdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcry
gaaephtiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1yovB (B:)
gsmavdggcgdtgdwegrwnhvkkflersgpfthpdfepsteslqflldtckvlvigagg
lgcellknlalsgfrqihvidmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpnc
nvvphfnkiqdfndtfyrqfhiivcgldsiiarrwingmlisllnyedgvldpssivpli
dggtegfkgnarvilpgmtaciectlelyppqvnfpmctiasmprlpehcieyvrmlqwp
keqpfgegvpldgddpehiqwifqkslerasqynirgvtyrltqgvvkriipavastnav
iaavcatevfkiatsayiplnnylvfndvdglytytfeaerkencpacsqlpqniqfsps
aklqevldyltnsaslqmkspaitatlegknrtlylqsvtsieertrpnlsktlkelglv
dgqelavadvttpqtvlfklhfts

    Sequence, based on observed residues (ATOM records): (download) 
    >1yovB (B:)
dwegrwnhvkkflersgpfthpdfepsteslqflldtckvlvigagglgcellknlalsg
frqihvidmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpncnvvphfnkiqdfn
dtfyrqfhiivcgldsiiarrwingmlisllnyedgvldpssivplidggtegfkgnarv
ilpgmtaciectlelyppqvnfpmctiasmprlpehcieyvrmlqwpkeqpfgegvpldg
ddpehiqwifqkslerasqynirgvtyrltqgvvkriipavastnaviaavcatevfkia
tsayiplnnylvfndvdglytytfeaerkencpacsqlpqniqlqevldyltnsaslqmk
spaitatrtlylqseertrpnllavadvttpqtvlfk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1yovC (C:)
mklmaqlgkllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsf
tiidgnqvsgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndp
sffcrftvvvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpd
naledlrldkpfpelrehfqsydldhmekkdhshtpwiviiakylaqwysetngripkty
kekedfrdlirqgilknengapedeenfeeaiknvntalnttqipssiedifnddrcini
tkqtpsfwilaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaav
gnhvakllqsigqapesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmd
npdneivlylmlravdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkdd
yvhefcrygaaephtiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

    Sequence, based on observed residues (ATOM records): (download) 
    >1yovC (C:)
keqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftiidgnqvsge
dagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsffcrftvvva
tqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnaledlrldkp
fpelrehfqsydldhmekkdhshtpwiviiakylaqwysetngripktykekedfrdlir
qgilknengapedeenfeeaiknvntalnttqipssiedifnddrcinitkqtpsfwila
ralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsi
gqapesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivlylm
lravdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcrygaa
ephtiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1yovD (D:)
gsmavdggcgdtgdwegrwnhvkkflersgpfthpdfepsteslqflldtckvlvigagg
lgcellknlalsgfrqihvidmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpnc
nvvphfnkiqdfndtfyrqfhiivcgldsiiarrwingmlisllnyedgvldpssivpli
dggtegfkgnarvilpgmtaciectlelyppqvnfpmctiasmprlpehcieyvrmlqwp
keqpfgegvpldgddpehiqwifqkslerasqynirgvtyrltqgvvkriipavastnav
iaavcatevfkiatsayiplnnylvfndvdglytytfeaerkencpacsqlpqniqfsps
aklqevldyltnsaslqmkspaitatlegknrtlylqsvtsieertrpnlsktlkelglv
dgqelavadvttpqtvlfklhfts

    Sequence, based on observed residues (ATOM records): (download) 
    >1yovD (D:)
hvkkflersgpfthpdfepsteslqflldtckvlvigagglgcellknlalsgfrqihvi
dmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpncnvvphfnkiqdfndtfyrqf
hiivcgldsiiarrwingmlisllnyedgvldpssivplidggtegfkgnarvilpgmta
ciectlelyppqvnfpmctiasmprlpehcieyvrmlqwpkeqpfgegvpldgddpehiq
wifqkslerasqynirgvtyrltqgvvkriipavastnaviaavcatevfkiatsayipl
nnylvfndvdglytytfeaerkencpacsqlpqniqlqevldyltnsaslqmkspaitnr
tlylqstsievadvttpqtvlf