PDB entry 1yho

View 1yho on RCSB PDB site
Description: Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures
Class: oxidoreductase
Keywords: DHFR, Inhibitor/Enzyme complex
Deposited on 2005-01-10, released 2005-11-22
The last revision prior to the SCOP 1.75 freeze date was dated 2005-11-22, with a file datestamp of 2007-06-04.
Experiment type: NMR25
Resolution: N/A
R-factor: N/A
AEROSPACI score: 0.01 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1yhoa1
  • Heterogens: NDP, TRR

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1yhoA (A:)
    vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
    peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
    ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
    vyeknd