PDB entry 1ye6

View 1ye6 on RCSB PDB site
Description: Crystal structure of the Lys-274 to Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NADP+
Class: oxidoreductase
Keywords: beta-alpha-barrel AKR aldo-keto reductase coenzyme specificity NADP, OXIDOREDUCTASE
Deposited on 2004-12-28, released 2005-02-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-11-16, with a file datestamp of 2011-11-11.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.192
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NAD(P)H-dependent D-xylose reductase
    Species: Candida tenuis [TaxId:45596]
    Gene: XYL1, XYLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot O74237 (Start-321)
      • engineered (273)
    Domains in SCOPe 2.07: d1ye6a_
  • Chain 'B':
    Compound: NAD(P)H-dependent D-xylose reductase
    Species: Candida tenuis [TaxId:45596]
    Gene: XYL1, XYLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot O74237 (Start-321)
      • engineered (273)
    Domains in SCOPe 2.07: d1ye6b_
  • Chain 'C':
    Compound: NAD(P)H-dependent D-xylose reductase
    Species: Candida tenuis [TaxId:45596]
    Gene: XYL1, XYLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot O74237 (Start-321)
      • engineered (273)
    Domains in SCOPe 2.07: d1ye6c_
  • Chain 'D':
    Compound: NAD(P)H-dependent D-xylose reductase
    Species: Candida tenuis [TaxId:45596]
    Gene: XYL1, XYLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot O74237 (Start-321)
      • engineered (273)
    Domains in SCOPe 2.07: d1ye6d_
  • Heterogens: SO4, NAP, NAD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1ye6A (A:)
msasipdiklssghlmpsigfgcwklanatageqvyqaikagyrlfdgaedygnekevgd
gvkraideglvkreeifltsklwnnyhdpknvetalnktladlkvdyvdlflihfpiafk
fvpieekyppgfycgdgnnfvyedvpiletwkaleklvaagkiksigvsnfpgallldll
rgatikpavlqvehhpylqqpkliefaqkagvtitayssfgpqsfvemnqgralntptlf
ahdtikaiaakynktpaevllrwaaqrgiaviprsnlperlvqnrsfntfdltkedfeei
akldiglrfndpwdwdnipifv

    Sequence, based on observed residues (ATOM records): (download) 
    >1ye6A (A:)
sipdiklssghlmpsigfgcwklanatageqvyqaikagyrlfdgaedygnekevgdgvk
raideglvkreeifltsklwnnyhdpknvetalnktladlkvdyvdlflihfpiafkfvp
ieekyppgfycgdgnnfvyedvpiletwkaleklvaagkiksigvsnfpgallldllrga
tikpavlqvehhpylqqpkliefaqkagvtitayssfgpqsfvemnqgralntptlfahd
tikaiaakynktpaevllrwaaqrgiaviprsnlperlvqnrsfntfdltkedfeeiakl
diglrfndpwdwdnipifv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1ye6B (B:)
msasipdiklssghlmpsigfgcwklanatageqvyqaikagyrlfdgaedygnekevgd
gvkraideglvkreeifltsklwnnyhdpknvetalnktladlkvdyvdlflihfpiafk
fvpieekyppgfycgdgnnfvyedvpiletwkaleklvaagkiksigvsnfpgallldll
rgatikpavlqvehhpylqqpkliefaqkagvtitayssfgpqsfvemnqgralntptlf
ahdtikaiaakynktpaevllrwaaqrgiaviprsnlperlvqnrsfntfdltkedfeei
akldiglrfndpwdwdnipifv

    Sequence, based on observed residues (ATOM records): (download) 
    >1ye6B (B:)
sipdiklssghlmpsigfgcwklanatageqvyqaikagyrlfdgaedygnekevgdgvk
raideglvkreeifltsklwnnyhdpknvetalnktladlkvdyvdlflihfpiafkfvp
ieekyppgfycgdgnnfvyedvpiletwkaleklvaagkiksigvsnfpgallldllrga
tikpavlqvehhpylqqpkliefaqkagvtitayssfgpqsfvemnqgralntptlfahd
tikaiaakynktpaevllrwaaqrgiaviprsnlperlvqnrsfntfdltkedfeeiakl
diglrfndpwdwdnipifv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1ye6C (C:)
msasipdiklssghlmpsigfgcwklanatageqvyqaikagyrlfdgaedygnekevgd
gvkraideglvkreeifltsklwnnyhdpknvetalnktladlkvdyvdlflihfpiafk
fvpieekyppgfycgdgnnfvyedvpiletwkaleklvaagkiksigvsnfpgallldll
rgatikpavlqvehhpylqqpkliefaqkagvtitayssfgpqsfvemnqgralntptlf
ahdtikaiaakynktpaevllrwaaqrgiaviprsnlperlvqnrsfntfdltkedfeei
akldiglrfndpwdwdnipifv

    Sequence, based on observed residues (ATOM records): (download) 
    >1ye6C (C:)
sipdiklssghlmpsigfgcwklanatageqvyqaikagyrlfdgaedygnekevgdgvk
raideglvkreeifltsklwnnyhdpknvetalnktladlkvdyvdlflihfpiafkfvp
ieekyppgfycgdgnnfvyedvpiletwkaleklvaagkiksigvsnfpgallldllrga
tikpavlqvehhpylqqpkliefaqkagvtitayssfgpqsfvemnqgralntptlfahd
tikaiaakynktpaevllrwaaqrgiaviprsnlperlvqnrsfntfdltkedfeeiakl
diglrfndpwdwdnipifv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1ye6D (D:)
msasipdiklssghlmpsigfgcwklanatageqvyqaikagyrlfdgaedygnekevgd
gvkraideglvkreeifltsklwnnyhdpknvetalnktladlkvdyvdlflihfpiafk
fvpieekyppgfycgdgnnfvyedvpiletwkaleklvaagkiksigvsnfpgallldll
rgatikpavlqvehhpylqqpkliefaqkagvtitayssfgpqsfvemnqgralntptlf
ahdtikaiaakynktpaevllrwaaqrgiaviprsnlperlvqnrsfntfdltkedfeei
akldiglrfndpwdwdnipifv

    Sequence, based on observed residues (ATOM records): (download) 
    >1ye6D (D:)
sipdiklssghlmpsigfgcwklanatageqvyqaikagyrlfdgaedygnekevgdgvk
raideglvkreeifltsklwnnyhdpknvetalnktladlkvdyvdlflihfpiafkfvp
ieekyppgfycgdgnnfvyedvpiletwkaleklvaagkiksigvsnfpgallldllrga
tikpavlqvehhpylqqpkliefaqkagvtitayssfgpqsfvemnqgralntptlfahd
tikaiaakynktpaevllrwaaqrgiaviprsnlperlvqnrsfntfdltkedfeeiakl
diglrfndpwdwdnipifv