PDB entry 1ycp
View 1ycp on RCSB PDB site
Description: the crystal structure of fibrinogen-aa peptide 1-23 (f8y) bound to bovine thrombin explains why the mutation of phe-8 to tyrosine strongly inhibits normal cleavage at arginine-16
Class: hydrolase/hydrolase substrate
Keywords: fibrinopeptide-a, complex (serine protease-peptide), thrombin, hydrolase-hydrolase substrate complex
Deposited on
1997-05-01, released
1998-05-06
The last revision prior to the SCOPe 2.01 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.183
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'F':
Compound: fibrinopeptide a-alpha
Database cross-references and differences (RAF-indexed):
- Chain 'H':
Compound: alpha thrombin
Species: Bos taurus [TaxId:9913]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d1ycp.1 - Chain 'J':
Compound: epsilon thrombin
Species: Bos taurus [TaxId:9913]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d1ycp.2 - Chain 'K':
Compound: epsilon thrombin
Species: Bos taurus [TaxId:9913]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d1ycp.2 - Chain 'L':
Compound: epsilon thrombin
Species: Bos taurus [TaxId:9913]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d1ycp.1 - Chain 'M':
Compound: epsilon thrombin
Species: Bos taurus [TaxId:9913]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d1ycp.2 - Chain 'N':
Compound: fibrinopeptide a-alpha
Database cross-references and differences (RAF-indexed):
- Heterogens: HOH
PDB Chain Sequences:
- Chain 'F':
No sequence available.
- Chain 'H':
Sequence, based on SEQRES records: (download)
>1ycpH (H:)
ivegqdaevglspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftvddll
vrigkhsrtryerkvekismldkiyihprynwkenldrdiallklkrpielsdyihpvcl
pdkqtaakllhagfkgrvtgwgnrretwttsvaevqpsvlqvvnlplverpvckastrir
itdnmfcagykpgegkrgdacegdsggpfvmkspynnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidrlgs
Sequence, based on observed residues (ATOM records): (download)
>1ycpH (H:)
ivegqdaevglspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftvddll
vrigkhsrtryerkvekismldkiyihprynwkenldrdiallklkrpielsdyihpvcl
pdkqtaakllhagfkgrvtgwgnrrevqpsvlqvvnlplverpvckastriritdnmfca
gykpgegkrgdacegdsggpfvmkspynnrwyqmgivswgegcdrdgkygfythvfrlkk
wiqkvid
- Chain 'J':
Sequence, based on SEQRES records: (download)
>1ycpJ (J:)
tsedhfqpffnektfgageadcglrplfekkqvqdqtekelfesyiegr
Sequence, based on observed residues (ATOM records): (download)
>1ycpJ (J:)
adcglrplfekkqvqdqtekelfesyieg
- Chain 'K':
Sequence, based on SEQRES records: (download)
>1ycpK (K:)
ivegqdaevglspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftvddll
vrigkhsrtryerkvekismldkiyihprynwkenldrdiallklkrpielsdyihpvcl
pdkqtaakllhagfkgrvtgwgnrretwtt
Sequence, based on observed residues (ATOM records): (download)
>1ycpK (K:)
ivegqdaevglspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftvddll
vrigkhsrtryerkvekismldkiyihprynwkenldrdiallklkrpielsdyihpvcl
pdkqtaakllhagfkgrvtgwgnrre
- Chain 'L':
Sequence, based on SEQRES records: (download)
>1ycpL (L:)
tsedhfqpffnektfgageadcglrplfekkqvqdqtekelfesyiegr
Sequence, based on observed residues (ATOM records): (download)
>1ycpL (L:)
adcglrplfekkqvqdqtekelfesyieg
- Chain 'M':
Sequence, based on SEQRES records: (download)
>1ycpM (M:)
svaevqpsvlqvvnlplverpvckastriritdnmfcagykpgegkrgdacegdsggpfv
mkspynnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidrlgs
Sequence, based on observed residues (ATOM records): (download)
>1ycpM (M:)
vqpsvlqvvnlplverpvckastriritdnmfcagykpgegkrgdacegdsggpfvmksp
ynnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvid
- Chain 'N':
No sequence available.