PDB entry 1ya3
View 1ya3 on RCSB PDB site
Description: Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension
Class: transcription
Keywords: mineralocorticoid receptor, steroid receptor, nuclear receptor transcription regulation, activating mutation, hypertension
Deposited on
2004-12-17, released
2005-05-24
The last revision prior to the SCOPe 2.07 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.34 Å
R-factor: 0.237
AEROSPACI score: 0.3
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Mineralocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C2, MCR, MLR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1ya3a_ - Chain 'B':
Compound: Mineralocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C2, MCR, MLR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1ya3b_ - Chain 'C':
Compound: Mineralocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C2, MCR, MLR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d1ya3c_ - Heterogens: STR, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1ya3A (A:)
ssraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlpg
fknlpledqitliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelc
qgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtk
apnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdqlp
kvesgnakplyfhrk
Sequence, based on observed residues (ATOM records): (download)
>1ya3A (A:)
spvmvleniepeivyagydtaenllstlnrlagkqmiqvvkwakvlpgfknlpledqitl
iqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqislqfvr
lqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtswqrfyqltklld
smhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyfh
- Chain 'B':
Sequence, based on SEQRES records: (download)
>1ya3B (B:)
ssraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlpg
fknlpledqitliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelc
qgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtk
apnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdqlp
kvesgnakplyfhrk
Sequence, based on observed residues (ATOM records): (download)
>1ya3B (B:)
pvmvleniepeivyadtaenllstlnrlagkqmiqvvkwakvlpgfknlpledqitliqy
swmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqislqfvrlql
tfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtswqrfyqltklldsmh
dlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyfh
- Chain 'C':
Sequence, based on SEQRES records: (download)
>1ya3C (C:)
ssraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlpg
fknlpledqitliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelc
qgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtk
apnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdqlp
kvesgnakplyfhrk
Sequence, based on observed residues (ATOM records): (download)
>1ya3C (C:)
spvmvlenievyagydsdtaenllstlnrlagkqmiqvvkwakvlpgfknlpledqitli
qyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqislqfvrl
qltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtswqrfyqltkllds
mhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyfh