PDB entry 1y7v

View 1y7v on RCSB PDB site
Description: X-ray structure of human acid-beta-glucosidase covalently bound to conduritol B epoxide
Class: hydrolase
Keywords: GAUCHER DISEASE, GLUCOSIDASE, GLUCOCEREBROSIDASE, CEREZYME, HYDROLASE, GLYCOSIDASE, SPHINGOLIPID METABOLISM, GLYCOPROTEIN, LYSOSOME, MEMBRANE, GAUCHER DISEASE, SIGNAL, DISEASE MUTATION, POLYMORPHISM, ALTERNATIVE INITIATION, PHARMACEUTICAL, Israel Structural Proteomics Center, ISPC, Structural Genomics
Deposited on 2004-12-10, released 2005-04-12
The last revision prior to the SCOP 1.73 freeze date was dated 2005-07-26, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.242
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glucosylceramidase
    Species: HOMO SAPIENS
    Gene: GBA, GC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (0-496)
      • engineered (494)
    Domains in SCOP 1.73: d1y7va1, d1y7va2
  • Chain 'B':
    Compound: glucosylceramidase
    Species: HOMO SAPIENS
    Gene: GBA, GC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (0-496)
      • engineered (494)
    Domains in SCOP 1.73: d1y7vb1, d1y7vb2
  • Heterogens: SO4, INS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1y7vA (A:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1y7vB (B:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq