PDB entry 1y6n

View 1y6n on RCSB PDB site
Description: Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain
Class: immune system
Keywords: helix bundle, receptor complex, immune system
Deposited on 2004-12-06, released 2005-05-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.206
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'L':
    Compound: Viral interleukin-10 homolog
    Species: Human herpesvirus 4 [TaxId:10376]
    Gene: BCRF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03180 (1-End)
      • modified residue (7)
      • modified residue (53)
      • modified residue (62)
      • engineered (72)
      • modified residue (125)
      • modified residue (139)
    Domains in SCOPe 2.07: d1y6nl1
  • Chain 'R':
    Compound: interleukin-10 receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: IL10RA, IL10R
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13651
      • engineered (28)
      • engineered (52)
      • engineered (88)
      • engineered (132)
      • engineered (155)
      • engineered (167)
    Domains in SCOPe 2.07: d1y6nr1, d1y6nr2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >1y6nL (L:)
    qcdnfpqmlrdlrdafsrvktffqtkdevdnlllkeslledfkgylgcqalsemiqfyle
    evmpqaenqdpeikdhvnslgenlktlrlrlrrchrflpcenkskaveqiknafnklqek
    giykamsefdifinyieaymtikar
    

    Sequence, based on observed residues (ATOM records): (download)
    >1y6nL (L:)
    cdnfpqmlrdlrdafsrvktffqtkdevdnlllkeslledfkgylgcqalsemiqfylee
    vmpqaenqdpeikdhvnslgenlktlrlrlrrchrflpcenkskaveqiknafnklqekg
    iykamsefdifinyieaymtik
    

  • Chain 'R':
    Sequence, based on SEQRES records: (download)
    >1y6nR (R:)
    hgtelpsppsvwfeaeffhhilhwtpipqqsestcyevallrygieswnsisqcsqtlsy
    dltavtldlyhsngyrarvravdgsrhsqwtvtntrfsvdevtltvgsvnleihngfilg
    kiqlprpkmapaqdtyesifshfreyeiairkvpgqftfthkkvkheqfslltsgevgef
    cvqvkpsvasrsnkgmwskeecisltrqyftvtn
    

    Sequence, based on observed residues (ATOM records): (download)
    >1y6nR (R:)
    gtelpsppsvwfeaeffhhilhwtpipqqsestcyevallrygieswnsisqcsqtlsyd
    ltavtldlyhsngyrarvravdgsrhsqwtvtntrfsvdevtltvgsvnleihngfilgk
    iqlprpkmapaqdtyesifshfreyeiairkvpgqftfthkkvkheqfslltsgevgefc
    vqvkpsvasrsnkgmwskeeci