PDB entry 1y5m

View 1y5m on RCSB PDB site
Description: The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes
Class: oxidoreductase
Keywords: rossmann fold, oxidoreductase
Deposited on 2004-12-02, released 2005-05-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.219
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Corticosteroid 11-beta-dehydrogenase, isozyme 1
    Species: Mus musculus [TaxId:10090]
    Gene: Hsd11b1, Hsd11
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1y5ma1
  • Chain 'B':
    Compound: Corticosteroid 11-beta-dehydrogenase, isozyme 1
    Species: Mus musculus [TaxId:10090]
    Gene: Hsd11b1, Hsd11
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1y5mb_
  • Heterogens: SO4, NDP, OCT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1y5mA (A:)
mhhhhhhneefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvs
rclelgaasahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsv
rrvmevnflsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffst
irtelyitkvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksev
yydkspltpillgnpgrkimeffslryynkdmfvsn

    Sequence, based on observed residues (ATOM records): (download) 
    >1y5mA (A:)
eefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvsrclelgaa
sahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsvrrvmevnf
lsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffstirtelyit
kvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksevyydksplt
pillgnpgrkimeffslryynkdmf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1y5mB (B:)
mhhhhhhneefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvs
rclelgaasahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsv
rrvmevnflsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffst
irtelyitkvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksev
yydkspltpillgnpgrkimeffslryynkdmfvsn

    Sequence, based on observed residues (ATOM records): (download) 
    >1y5mB (B:)
eefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvsrclelgaa
sahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsvrrvmevnf
lsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffstirtelyit
kvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksevyydksplt
pillgnpgrkimeffslryynkdmf