PDB entry 1xr3

View 1xr3 on RCSB PDB site
Description: Actinorhodin Polyketide Ketoreductase with NADP and the Inhibitor Isoniazid bound
Class: oxidoreductase
Keywords: protein-inhibitor complex, oxidoreductase
Deposited on 2004-10-13, released 2005-09-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.71 Å
R-factor: 0.212
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Actinorhodin Polyketide Ketoreductase
    Species: Streptomyces coelicolor [TaxId:1902]
    Gene: actIII
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xr3a1
  • Chain 'B':
    Compound: Actinorhodin Polyketide Ketoreductase
    Species: Streptomyces coelicolor [TaxId:1902]
    Gene: actIII
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xr3b_
  • Heterogens: NAP, ISZ

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1xr3A (A:)
matqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgr
tcdvrsvpeiealvaavverygpvdvlvnnagrpgggataeladelwldvvetnltgvfr
vtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgi
tvnavcpgfvetpmaasvrehysdiwevsteeafdritarvpigryvqpsevaemvayli
gpgaaavtaqalnvcgglgny

    Sequence, based on observed residues (ATOM records): (download) 
    >1xr3A (A:)
sevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgrtcdvr
svpeiealvaavverygpvdvlvnnagrpgggataeladelwldvvetnltgvfrvtkqv
lkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgitvnav
cpgfvetpmaasvrehysdiwevsteeafdritarvpigryvqpsevaemvayligpgaa
avtaqalnvcgglgny

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1xr3B (B:)
matqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgr
tcdvrsvpeiealvaavverygpvdvlvnnagrpgggataeladelwldvvetnltgvfr
vtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgi
tvnavcpgfvetpmaasvrehysdiwevsteeafdritarvpigryvqpsevaemvayli
gpgaaavtaqalnvcgglgny

    Sequence, based on observed residues (ATOM records): (download) 
    >1xr3B (B:)
matqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgr
tcdvrsvpeiealvaavverygpvdvlvnnagrpgggataeladelwldvvetnltgvfr
vtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgi
tvnavcpgfvetpmaasvrevsteeafdritarvpigryvqpsevaemvayligpgaaav
taqalnvcgglgny