PDB entry 1xmi

View 1xmi on RCSB PDB site
Description: Crystal structure of human F508A NBD1 domain with ATP
Class: membrane protein, hydrolase
Keywords: CFTR; NBD1 domain; F508A; cystic fibrosis; nucleotide-binding domain 1, MEMBRANE PROTEIN, HYDROLASE
Deposited on 2004-10-02, released 2004-11-09
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.232
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569 (0-End)
      • cloning artifact (0)
      • engineered (41)
      • engineered (120)
      • engineered (279)
    Domains in SCOPe 2.06: d1xmia1, d1xmia2
  • Chain 'B':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569 (0-End)
      • cloning artifact (0)
      • engineered (41)
      • engineered (120)
      • engineered (279)
    Domains in SCOPe 2.06: d1xmib1, d1xmib2
  • Chain 'C':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569
      • engineered (41)
      • engineered (120)
      • engineered (279)
    Domains in SCOPe 2.06: d1xmic_
  • Chain 'D':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569 (0-End)
      • cloning artifact (0)
      • engineered (41)
      • engineered (120)
      • engineered (279)
    Domains in SCOPe 2.06: d1xmid1, d1xmid2
  • Chain 'E':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569
      • engineered (41)
      • engineered (120)
      • engineered (279)
    Domains in SCOPe 2.06: d1xmie_
  • Heterogens: MG, ATP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1xmiA (A:)
sttevvmenvtafweegfgelfekakqnnnnrktsngddslsfsnfsllgtpvlkdinfk
iergqllavagstgagktsllmmimgelepsegkikhsgrisfcsqfswimpgtikenii
agvsydeyryrsvikacqleediskfaekdnivlgeggitlsggqrarislaravykdad
lylldspfgyldvltekeifescvcklmanktrilvtskmehlkkadkililhegssyfy
gtfselqnlqpdfssklmgcdsfdqfsaerrnsiltetlrrfslegdapvs

    Sequence, based on observed residues (ATOM records): (download) 
    >1xmiA (A:)
sttevvmenvtafweegfgelfeksfsnfsllgtpvlkdinfkiergqllavagstgagk
tsllmmimgelepsegkikhsgrisfcsqfswimpgtikeniiagvsydeyryrsvikac
qleediskfaekdnivlgeggitlsggqrarislaravykdadlylldspfgyldvltek
eifescvcklmanktrilvtskmehlkkadkililhegssyfygtfselqnlqpdfsskl
mgcdsfdqfsaerrnsiltetlrrfsl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1xmiB (B:)
sttevvmenvtafweegfgelfekakqnnnnrktsngddslsfsnfsllgtpvlkdinfk
iergqllavagstgagktsllmmimgelepsegkikhsgrisfcsqfswimpgtikenii
agvsydeyryrsvikacqleediskfaekdnivlgeggitlsggqrarislaravykdad
lylldspfgyldvltekeifescvcklmanktrilvtskmehlkkadkililhegssyfy
gtfselqnlqpdfssklmgcdsfdqfsaerrnsiltetlrrfslegdapvs

    Sequence, based on observed residues (ATOM records): (download) 
    >1xmiB (B:)
sttevvmenvtafweegfgelfekaksfsnfsllgtpvlkdinfkiergqllavagstga
gktsllmmimgelepsegkikhsgrisfcsqfswimpgtikeniiagvsydeyryrsvik
acqleediskivltlsggqrarislaravykdadlylldspfgyldvltekeifescvck
lmanktrilvtskmehlkkadkililhegssyfygtfselqnlqpdfssklmgcdsfdqf
saerrnsiltetlrrfsl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1xmiC (C:)
sttevvmenvtafweegfgelfekakqnnnnrktsngddslsfsnfsllgtpvlkdinfk
iergqllavagstgagktsllmmimgelepsegkikhsgrisfcsqfswimpgtikenii
agvsydeyryrsvikacqleediskfaekdnivlgeggitlsggqrarislaravykdad
lylldspfgyldvltekeifescvcklmanktrilvtskmehlkkadkililhegssyfy
gtfselqnlqpdfssklmgcdsfdqfsaerrnsiltetlrrfslegdapvs

    Sequence, based on observed residues (ATOM records): (download) 
    >1xmiC (C:)
ttevvmenvtafweegfgelfekakqnsfsnfsllgtpvlkdinfkiergqllavagstg
agktsllmmimgelepsegkikhsgrisfcsqfswimpgtikeniiagvsydeyryrsvi
kacqleediskfaekdnivlgeggitlsggqrarislaravykdadlylldspfgyldvl
tekeifescvcklmanktrilvtskmehlkkadkililhegssyfygtfselqnlqpdfs
sklmgcdsfdqfsaerrnsiltetlrrfsl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1xmiD (D:)
sttevvmenvtafweegfgelfekakqnnnnrktsngddslsfsnfsllgtpvlkdinfk
iergqllavagstgagktsllmmimgelepsegkikhsgrisfcsqfswimpgtikenii
agvsydeyryrsvikacqleediskfaekdnivlgeggitlsggqrarislaravykdad
lylldspfgyldvltekeifescvcklmanktrilvtskmehlkkadkililhegssyfy
gtfselqnlqpdfssklmgcdsfdqfsaerrnsiltetlrrfslegdapvs

    Sequence, based on observed residues (ATOM records): (download) 
    >1xmiD (D:)
sttevvmenvtafweegfgelfedslsfsnfsllgtpvlkdinfkiergqllavagstga
gktsllmmimgelepsegkikhsgrisfcsqfswimpgtikeniiagvsydeyryrsvik
acqleediskfaekdnivlgeitlsggqrarislaravykdadlylldspfgyldvltek
eifescvcklmanktrilvtskmehlkkadkililhegssyfygtfselqnlqpdfsskl
mgcdsfdqfsaerrnsiltetlrrfsle

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1xmiE (E:)
sttevvmenvtafweegfgelfekakqnnnnrktsngddslsfsnfsllgtpvlkdinfk
iergqllavagstgagktsllmmimgelepsegkikhsgrisfcsqfswimpgtikenii
agvsydeyryrsvikacqleediskfaekdnivlgeggitlsggqrarislaravykdad
lylldspfgyldvltekeifescvcklmanktrilvtskmehlkkadkililhegssyfy
gtfselqnlqpdfssklmgcdsfdqfsaerrnsiltetlrrfslegdapvs

    Sequence, based on observed residues (ATOM records): (download) 
    >1xmiE (E:)
ttevvmenvtafweegfgelfeksfsnfsllgtpvlkdinfkiergqllavagstgagkt
sllmmimgelepsegkikhsgrisfcsqfswimpgtikeniiagvsydeyryrsvikacq
leediskfaekdnivlgeggitlsggqrarislaravykdadlylldspfgyldvlteke
ifescvcklmanktrilvtskmehlkkadkililhegssyfygtfselqnlqpdfssklm
gcdsfdqfsaerrnsiltetlrrfsl