PDB entry 1xm6

View 1xm6 on RCSB PDB site
Description: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Mesopram
Class: hydrolase
Keywords: PDE4B, (R)-Mesopram
Deposited on 2004-10-01, released 2004-12-14
The last revision prior to the SCOP 1.73 freeze date was dated 2004-12-14, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 1.92 Å
R-factor: 0.202
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    Species: HOMO SAPIENS
    Gene: PDE4B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07343
      • modified residue (63)
      • modified residue (189)
      • modified residue (301)
    Domains in SCOP 1.73: d1xm6a_
  • Chain 'B':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    Species: HOMO SAPIENS
    Gene: PDE4B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07343
      • modified residue (63)
      • modified residue (189)
      • modified residue (301)
    Domains in SCOP 1.73: d1xm6b_
  • Heterogens: ZN, MG, 5RM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1xm6A (A:)
mgsshhhhhhssglvprgshmsisrfgvntenedhlakeledlnkwglnifnvagyshnr
pltcimyaifqerdllktfrissdtfitymmtledhyhsdvayhnslhaadvaqsthvll
stpaldavftdleilaaifaaaihdvdhpgvsnqflintnselalmyndesvlenhhlav
gfkllqeehcdifmnltkkqrqtlrkmvidmvlatdmskhmslladlktmvetkkvtssg
vllldnytdriqvlrnmvhcadlsnptkslelyrqwtdrimeeffqqgdkerergmeisp
mcdkhtasveksqvgfidyivhplwetwadlvqpdaqdildtlednrnwyqsmipqspsp
pldeqnrdcqglmekfqfeltldeedsegpekegeghs

    Sequence, based on observed residues (ATOM records): (download) 
    >1xm6A (A:)
edhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfrissdtfitymmt
ledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaaihdvdhpgvs
nqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqtlrkmvidmv
latdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadlsnptkslel
yrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhplwetwadlv
qpdaqdildtlednrnwyqsmipcqglmekfqfeltld

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1xm6B (B:)
mgsshhhhhhssglvprgshmsisrfgvntenedhlakeledlnkwglnifnvagyshnr
pltcimyaifqerdllktfrissdtfitymmtledhyhsdvayhnslhaadvaqsthvll
stpaldavftdleilaaifaaaihdvdhpgvsnqflintnselalmyndesvlenhhlav
gfkllqeehcdifmnltkkqrqtlrkmvidmvlatdmskhmslladlktmvetkkvtssg
vllldnytdriqvlrnmvhcadlsnptkslelyrqwtdrimeeffqqgdkerergmeisp
mcdkhtasveksqvgfidyivhplwetwadlvqpdaqdildtlednrnwyqsmipqspsp
pldeqnrdcqglmekfqfeltldeedsegpekegeghs

    Sequence, based on observed residues (ATOM records): (download) 
    >1xm6B (B:)
edhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfrissdtfitymmt
ledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaaihdvdhpgvs
nqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqtlrkmvidmv
latdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadlsnptkslel
yrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhplwetwadlv
qpdaqdildtlednrnwyqsmipglmekfqfelt