PDB entry 1xh9

View 1xh9 on RCSB PDB site
Description: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
Class: transferase/transferase inhibitor
Keywords: PKA, kinase-inhibitor-complex, serine/threonine-protein kinase, balanol derivative, TRANSFERASE/TRANSFERASE INHIBITOR COMPLEX
Deposited on 2004-09-17, released 2005-09-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.64 Å
R-factor: 0.166
AEROSPACI score: 0.59 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase, alpha-catalytic subunit
    Species: Bos taurus [TaxId:9913]
    Gene: PRKACA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00517 (Start-349)
      • engineered (83)
      • engineered (122)
      • engineered (172)
      • engineered (180)
      • engineered (186)
      • modified residue (196)
      • modified residue (337)
    Domains in SCOPe 2.08: d1xh9a_
  • Chain 'B':
    Compound: cAMP-dependent protein kinase inhibitor, alpha form
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: R69, BU3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1xh9A (A:)
gnaaaakkgseqesvkeflakakedflkkwenpaqntahldqferiktlgtgsfgrvmlv
khmetgnhyamkildkqkvvklkeiehtlnekrilqavnfpflvklefsfkdnsnlymvm
eyapggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenlmidqqgyi
kvtdfglakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffa
dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfatt
dwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

    Sequence, based on observed residues (ATOM records): (download) 
    >1xh9A (A:)
esvkeflakakedflkkwenpaqntahldqferiktlgtgsfgrvmlvkhmetgnhyamk
ildkqkvvklkeiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyapggemfshl
rrigrfsepharfyaaqivltfeylhsldliyrdlkpenlmidqqgyikvtdfglakrvk
grtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivs
gkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkvea
pfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

  • Chain 'B':
    No sequence available.