PDB entry 1xds

View 1xds on RCSB PDB site
Description: Crystal structure of Aclacinomycin-10-hydroxylase (RdmB) in complex with S-adenosyl-L-methionine (SAM) and 11-deoxy-beta-rhodomycin (DbrA)
Class: transferase
Keywords: Anthracycline; hydroxylase; S-adenosyl-L-methionine; streptomyces; polyketide antibiotics; divergent evolution, Structural Proteomics in Europe, SPINE, Structural Genomics
Deposited on 2004-09-08, released 2004-11-23
The last revision prior to the SCOP 1.73 freeze date was dated 2005-02-22, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.253
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein RdmB
    Species: Streptomyces purpurascens
    Gene: rdmb
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q54527
      • modified residue (30)
      • modified residue (95)
      • modified residue (162)
      • modified residue (195)
      • modified residue (307)
      • modified residue (311)
    Domains in SCOP 1.73: d1xdsa1, d1xdsa2
  • Chain 'B':
    Compound: Protein RdmB
    Species: Streptomyces purpurascens
    Gene: rdmb
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q54527
      • modified residue (30)
      • modified residue (95)
      • modified residue (162)
      • modified residue (195)
      • modified residue (307)
      • modified residue (311)
    Domains in SCOP 1.73: d1xdsb1, d1xdsb2
  • Heterogens: SAM, DRA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1xdsA (A:)
msssspgepleptdqdldvllknlgnlvtpmalrvaatlrlvdhllagadtlagladrtd
thpqalsrlvrhltvvgvleggekqgrplrptrlgmlladghpaqqrawldlngavshad
laftglldvvrtgrpayagrygrpfwedlsadvaladsfdalmscdedlayeapadaydw
savrhvldvgggnggmlaaialraphlrgtlvelagpaerarrrfadagladrvtvaegd
ffkplpvtadvvllsfvllnwsdedaltilrgcvralepggrllvldradvegdgadrff
stlldlrmltfmggrvrtrdevvdlagsaglalasertsgsttlpfdfsileftavseea
apaaqasealpaqe

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdsA (A:)
leptdqdldvllknlgnlvtpmalrvaatlrlvdhllagadtlagladrtdthpqalsrl
vrhltvvgvleggerplrptrlgmlladghpaqqrawldlngavshadlaftglldvvrt
grpayagrygrpfwedlsadvaladsfdalmscddaydwsavrhvldvgggnggmlaaia
lraphlrgtlvelagpaerarrrfadagladrvtvaegdffkplpvtadvvllsfvllnw
sdedaltilrgcvralepggrllvldradvegdgadrffstlldlrmltfmggrvrtrde
vvdlagsaglalasertsgsttlpfdfsileftavs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1xdsB (B:)
msssspgepleptdqdldvllknlgnlvtpmalrvaatlrlvdhllagadtlagladrtd
thpqalsrlvrhltvvgvleggekqgrplrptrlgmlladghpaqqrawldlngavshad
laftglldvvrtgrpayagrygrpfwedlsadvaladsfdalmscdedlayeapadaydw
savrhvldvgggnggmlaaialraphlrgtlvelagpaerarrrfadagladrvtvaegd
ffkplpvtadvvllsfvllnwsdedaltilrgcvralepggrllvldradvegdgadrff
stlldlrmltfmggrvrtrdevvdlagsaglalasertsgsttlpfdfsileftavseea
apaaqasealpaqe

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdsB (B:)
pleptdqdldvllknlgnlvtpmalrvaatlrlvdhlladrtdthpqalsrlvrhltvvg
vleggerplrptrlgmlladghpaqqrawldlngavshadlaftglldvvrtgrpayagr
ygrpfwedlsadvaladsfdalmseapadaydwsavrhvldvgggnggmlaaialraphl
rgtlvelagpaerarrrfadagladrvtvaegdffkplpvtadvvllsfvllnwsdedal
tilrgcvralepggrllvldradvegdgadrffstlldlrmltfmggrvrtrdevvdlag
saglalasertsgsttlpfdfsileftavs