PDB entry 1xdm

View 1xdm on RCSB PDB site
Description: Structure of human aldolase B associated with hereditary fructose intolerance (A149P), at 291K
Class: lyase
Keywords: alpha/beta barrel, lyase
Deposited on 2004-09-07, released 2005-03-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.271
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fructose-bisphosphate aldolase B
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDOB, ALDB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05062
      • engineered (150)
    Domains in SCOPe 2.07: d1xdma_
  • Chain 'B':
    Compound: Fructose-bisphosphate aldolase B
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDOB, ALDB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05062
      • engineered (150)
    Domains in SCOPe 2.07: d1xdmb_
  • Chain 'C':
    Compound: Fructose-bisphosphate aldolase B
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDOB, ALDB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1xdmc_
  • Chain 'D':
    Compound: Fructose-bisphosphate aldolase B
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDOB, ALDB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05062
      • engineered (150)
    Domains in SCOPe 2.07: d1xdmd_
  • Chain 'W':
    Compound: Fructose-bisphosphate aldolase B
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDOB, ALDB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05062
      • engineered (150)
    Domains in SCOPe 2.07: d1xdmw_
  • Chain 'X':
    Compound: Fructose-bisphosphate aldolase B
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDOB, ALDB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1xdmx_
  • Chain 'Y':
    Compound: Fructose-bisphosphate aldolase B
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDOB, ALDB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05062
      • engineered (150)
    Domains in SCOPe 2.07: d1xdmy_
  • Chain 'Z':
    Compound: Fructose-bisphosphate aldolase B
    Species: Homo sapiens [TaxId:9606]
    Gene: ALDOB, ALDB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1xdmz_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1xdmA (A:)
gsahrfpaltqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqf
reilfsvdssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgikldqggaplagt
nkettiqgldglsercaqykkdgvdfgkwrpvlriadqcpsslaiqenanalaryasicq
qnglvpivepevipdgdhdlehcqyvtekvlaavykalndhhvylegtllkpnmvtagha
ctkkytpeqvamatvtalhrtvpaavpgicflsggmseedatlnlnainlcplpkpwkls
fsygralqasalaawggkaankeatqeafmkramancqaakgqyvhtgssgaastqslft
acyty

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdmA (A:)
paltqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqfreilfs
vdssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgikldgldglsercaqykkd
gvdfgkwrpsslaiqenanalaryasicqqnglvpivepevidhdlehcqyvtekvlaav
ykalndhhvylegtllkpnmvtaytpeqvamatvtalhrtvpaavpgicflsggmseeda
tlnlnainlcplpkpwklsfsygralqasalaawggkaankeatqeafmkramancqaak
gqy

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1xdmB (B:)
gsahrfpaltqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqf
reilfsvdssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgikldqggaplagt
nkettiqgldglsercaqykkdgvdfgkwrpvlriadqcpsslaiqenanalaryasicq
qnglvpivepevipdgdhdlehcqyvtekvlaavykalndhhvylegtllkpnmvtagha
ctkkytpeqvamatvtalhrtvpaavpgicflsggmseedatlnlnainlcplpkpwkls
fsygralqasalaawggkaankeatqeafmkramancqaakgqyvhtgssgaastqslft
acyty

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdmB (B:)
altqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqfreilfsv
dssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgiklddglsercaqykkdgvd
fgkwrpsslaiqenanalaryasicqqnglvpivepevipddlehcqyvtekvlaavyka
lndhhvylegtllkpnmvtkkytpeqvamatvtalhrtvpaavpgicflsggmseedatl
nlnainlcplpkpwklsfsygralqasalaawggkaankeatqeafmkramancqaakgq
yvht

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1xdmC (C:)
gsahrfpaltqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqf
reilfsvdssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgikldqggaplagt
nkettiqgldglsercaqykkdgvdfgkwrpvlriadqcpsslaiqenanalaryasicq
qnglvpivepevipdgdhdlehcqyvtekvlaavykalndhhvylegtllkpnmvtagha
ctkkytpeqvamatvtalhrtvpaavpgicflsggmseedatlnlnainlcplpkpwkls
fsygralqasalaawggkaankeatqeafmkramancqaakgqyvhtgssgaastqslft
acyty

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdmC (C:)
altqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqfreilfsv
dssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgikldlsercaqykkdgvdfg
kwsslaiqenanalaryasicqqnglvpivepevipdlehcqyvtekvlaavykalndhh
vylegtllkpnmvtkkytpeqvamatvtalhrtvpaavpgicflsggmseedatlnlnai
nlcplpkpwklsfsygralqasalaawggkaankeatqeafmkramancqaakgqyvht

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1xdmD (D:)
gsahrfpaltqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqf
reilfsvdssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgikldqggaplagt
nkettiqgldglsercaqykkdgvdfgkwrpvlriadqcpsslaiqenanalaryasicq
qnglvpivepevipdgdhdlehcqyvtekvlaavykalndhhvylegtllkpnmvtagha
ctkkytpeqvamatvtalhrtvpaavpgicflsggmseedatlnlnainlcplpkpwkls
fsygralqasalaawggkaankeatqeafmkramancqaakgqyvhtgssgaastqslft
acyty

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdmD (D:)
altqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqfreilfsv
dssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgiklddglsercaqykkdgvd
fgkwrppsslaiqenanalaryasicqqnglvpivepedlehcqyvtekvlaavykalnd
hhvylegtllkpnmvtytpeqvamatvtalhrtvpaavpgicflsggmseedatlnlnai
nlcplpkpwklsfsygralqasalaawggkaankeatqeafmkramancqaakgqy

  • Chain 'W':
    Sequence, based on SEQRES records: (download) 
    >1xdmW (W:)
gsahrfpaltqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqf
reilfsvdssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgikldqggaplagt
nkettiqgldglsercaqykkdgvdfgkwrpvlriadqcpsslaiqenanalaryasicq
qnglvpivepevipdgdhdlehcqyvtekvlaavykalndhhvylegtllkpnmvtagha
ctkkytpeqvamatvtalhrtvpaavpgicflsggmseedatlnlnainlcplpkpwkls
fsygralqasalaawggkaankeatqeafmkramancqaakgqyvhtgssgaastqslft
acyty

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdmW (W:)
altqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqfreilfsv
dssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgiklglsercaqykkdgvdfg
kwrppsslaiqenanalaryasicqqnglvpivepevhdlehcqyvtekvlaavykalnd
hhvylegtllkpnmvtytpeqvamatvtalhrtvpaavpgicflsggmseedatlnlnai
nlcplpkpwklsfsygralqasalaawggkaankeatqeafmkramancqaakgqyv

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >1xdmX (X:)
gsahrfpaltqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqf
reilfsvdssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgikldqggaplagt
nkettiqgldglsercaqykkdgvdfgkwrpvlriadqcpsslaiqenanalaryasicq
qnglvpivepevipdgdhdlehcqyvtekvlaavykalndhhvylegtllkpnmvtagha
ctkkytpeqvamatvtalhrtvpaavpgicflsggmseedatlnlnainlcplpkpwkls
fsygralqasalaawggkaankeatqeafmkramancqaakgqyvhtgssgaastqslft
acyty

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdmX (X:)
altqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqfreilfsv
dssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgikldlsercaqykkdgvdfg
kwsslaiqenanalaryasicqqnglvpivepevipdlehcqyvtekvlaavykalndhh
vylegtllkpnmvtaactkkytpeqvamatvtalhrtvpaavpgicflsggmseedatln
lnainlcplpkpwklsfsygralqasalaawggkaankeatqeafmkramancqaakgqy
vh

  • Chain 'Y':
    Sequence, based on SEQRES records: (download) 
    >1xdmY (Y:)
gsahrfpaltqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqf
reilfsvdssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgikldqggaplagt
nkettiqgldglsercaqykkdgvdfgkwrpvlriadqcpsslaiqenanalaryasicq
qnglvpivepevipdgdhdlehcqyvtekvlaavykalndhhvylegtllkpnmvtagha
ctkkytpeqvamatvtalhrtvpaavpgicflsggmseedatlnlnainlcplpkpwkls
fsygralqasalaawggkaankeatqeafmkramancqaakgqyvhtgssgaastqslft
acyty

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdmY (Y:)
altqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqfreilfsv
dssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgiklddglsercaqykkdgvd
fgkwrpsslaiqenanalaryasicqqnglvpivepevipddlehcqyvtekvlaavyka
lndhhvylegtllkpnmvtkkytpeqvamatvtalhrtvpaavpgicflsggmseedatl
nlnainlcplpkpwklsfsygralqasalaawggkaankeatqeafmkramancqaakgq
yvht

  • Chain 'Z':
    Sequence, based on SEQRES records: (download) 
    >1xdmZ (Z:)
gsahrfpaltqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqf
reilfsvdssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgikldqggaplagt
nkettiqgldglsercaqykkdgvdfgkwrpvlriadqcpsslaiqenanalaryasicq
qnglvpivepevipdgdhdlehcqyvtekvlaavykalndhhvylegtllkpnmvtagha
ctkkytpeqvamatvtalhrtvpaavpgicflsggmseedatlnlnainlcplpkpwkls
fsygralqasalaawggkaankeatqeafmkramancqaakgqyvhtgssgaastqslft
acyty

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdmZ (Z:)
paltqeqkkelseiaqsivangkgilaadesvgtmgnrlqrikventeenrrqfreilfs
vdssinqsiggvilfhetlyqkdsqgklfrnilkekgivvgiklddglsercaqykkdgv
dfgkwrsslaiqenanalaryasicqqnglvpivepedlehcqyvtekvlaavykalndh
hvylegtllkpnmvtytpeqvamatvtalhrtvpaavpgicflsggmseedatlnlnain
lcplpkpwklsfsygralqasalaawggkaankeatqeafmkramancqaakgqy