PDB entry 1xdk

View 1xdk on RCSB PDB site
Description: Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator
Class: hormone/growth factor receptor
Keywords: Nuclear Receptor, Coactivator, Ligand
Deposited on 2004-09-07, released 2004-11-09
The last revision prior to the SCOP 1.75 freeze date was dated 2005-01-18, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.253
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Retinoic acid receptor RXR-alpha
    Species: MUS MUSCULUS
    Gene: RXRA, NR2B1
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1xdka_
  • Chain 'B':
    Compound: Retinoic acid receptor, beta
    Species: MUS MUSCULUS
    Gene: Rarb, Nr1b2
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1xdkb_
  • Chain 'C':
    Compound: Thyroid Receptor Associated Protein 220
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Thyroid Receptor Associated Protein 220
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Retinoic acid receptor RXR-alpha
    Species: MUS MUSCULUS
    Gene: RXRA, NR2B1
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1xdke_
  • Chain 'F':
    Compound: Retinoic acid receptor, beta
    Species: MUS MUSCULUS
    Gene: Rarb, Nr1b2
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1xdkf_
  • Chain 'G':
    Compound: Thyroid Receptor Associated Protein 220
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Thyroid Receptor Associated Protein 220
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: REA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1xdkA (A:)
sanedmpvekileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlvewak
riphfselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsagvga
ifdrvltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasleayc
khkypeqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemleaphqat

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdkA (A:)
anedmpvekileaelaveppndpvtnicqaadkqlftlvewakriphfselplddqvill
ragwnelliasfshrsiavkdgillatglhvhrnsahsagvgaifdrvltelvskmrdmq
mdktelgclraivlfnpdskglsnpaevealrekvyasleayckhkypeqpgrfaklllr
lpalrsiglkclehlfffkligdtpidtflmemleap

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1xdkB (B:)
mskesvrndrnkkkkepskqectesyemtaelddltekirkahqetfpslcqlgkyttns
sadhrvrldlglwdkfselatkciikivefakrlpgftgltiadqitllkaacldililr
ictrytpeqdtmtfsdgltlnrtqmhnagfgpltdlvftfanqllplemddtetgllsai
clicgdrqdleeptkvdklqepllealkiyirkrrpskphmfpkilmkitdlrsisakga
ervitlkmeipgsmppliqemlenseghepltpsssgniaehspsvspssvensgvsqsp
llq

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdkB (B:)
aelddltekirkahqetfpslcqlgkyttnssadhrvrldlglwdkfselatkciikive
fakrlpgftgltiadqitllkaacldililrictrytpeqdtmtfsdgltlnrtqmhnag
fgpltdlvftfanqllplemddtetgllsaiclicgdrqdleeptkvdklqepllealki
yirkrrpskphmfpkilmkitdlrsisakgaervitlkmeipgsmppliqemlenseghe
pltps

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1xdkE (E:)
sanedmpvekileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlvewak
riphfselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsagvga
ifdrvltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyasleayc
khkypeqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemleaphqat

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdkE (E:)
anedmpvekileaelaveppndpvtnicqaadkqlftlvewakriphfselplddqvill
ragwnelliasfshrsiavkdgillatglhvhrnsahsagvgaifdrvltelvskmrdmq
mdktelgclraivlfnpdskglsnpaevealrekvyasleayckhkypeqpgrfaklllr
lpalrsiglkclehlfffkligdtpidtflmemleap

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1xdkF (F:)
mskesvrndrnkkkkepskqectesyemtaelddltekirkahqetfpslcqlgkyttns
sadhrvrldlglwdkfselatkciikivefakrlpgftgltiadqitllkaacldililr
ictrytpeqdtmtfsdgltlnrtqmhnagfgpltdlvftfanqllplemddtetgllsai
clicgdrqdleeptkvdklqepllealkiyirkrrpskphmfpkilmkitdlrsisakga
ervitlkmeipgsmppliqemlenseghepltpsssgniaehspsvspssvensgvsqsp
llq

    Sequence, based on observed residues (ATOM records): (download) 
    >1xdkF (F:)
aelddltekirkahqetfpslcqlgkyttnssadhrvrldlglwdkfselatkciikive
fakrlpgftgltiadqitllkaacldililrictrytpeqdtmtfsdgltlnrtqmhnag
fgpltdlvftfanqllplemddtetgllsaiclicgdrqdleeptkvdklqepllealki
yirkrrpskphmfpkilmkitdlrsisakgaervitlkmeipgsmppliqemlenseghe
pltps

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.