PDB entry 1xcg

View 1xcg on RCSB PDB site
Description: Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF
Class: signaling protein activator/signaling protein
Keywords: X-ray crystallography; regulation of RhoA GTPase; protein complex, SIGNALING PROTEIN ACTIVATOR/SIGNALING PROTEIN COMPLEX
Deposited on 2004-09-01, released 2004-12-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-19.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.235
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Rho guanine nucleotide exchange factor 11
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF11, KIAA0380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1xcga1, d1xcga2
  • Chain 'B':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARHA, ARH12, RHO12
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61586 (0-177)
      • engineered (22)
    Domains in SCOPe 2.07: d1xcgb_
  • Chain 'E':
    Compound: Rho guanine nucleotide exchange factor 11
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF11, KIAA0380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1xcge1, d1xcge2
  • Chain 'F':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARHA, ARH12, RHO12
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61586 (0-177)
      • engineered (22)
    Domains in SCOPe 2.07: d1xcgf_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1xcgA (A:)
    qnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpre
    elarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqfc
    syqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesii
    khteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpla
    aefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchsktav
    gssdskqtfspvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwmel
    leeavrna
    

    Sequence, based on observed residues (ATOM records): (download)
    >1xcgA (A:)
    qnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpre
    elarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqfc
    syqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesii
    khteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpla
    aefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkctfspvl
    klnavlirsvatdkraffiictsklgppqiyelvaltssdkntwmelleeavrna
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1xcgB (B:)
    airkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvelalwdtag
    qedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlr
    ndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >1xcgE (E:)
    qnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpre
    elarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqfc
    syqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesii
    khteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpla
    aefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchsktav
    gssdskqtfspvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwmel
    leeavrna
    

    Sequence, based on observed residues (ATOM records): (download)
    >1xcgE (E:)
    qnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpre
    elarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqfc
    syqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesii
    khteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpla
    aefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchsktfs
    pvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwmelleeavrna
    

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1xcgF (F:)
    airkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvelalwdtag
    qedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlr
    ndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq