PDB entry 1xbc

View 1xbc on RCSB PDB site
Description: Crystal structure of the syk tyrosine kinase domain with Staurosporin
Class: transferase
Keywords: staurosporine, SYK, spleen typrosine kinase, active conformation, structural genomics, Structural GenomiX, Transferase
Deposited on 2004-08-30, released 2004-11-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-02-03, with a file datestamp of 2021-01-29.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase SYK
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43405 (Start-282)
      • cloning artifact (283)
    Domains in SCOPe 2.08: d1xbca1, d1xbca2
  • Heterogens: STU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1xbcA (A:)
maleeirpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpa
lkdellaeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdknii
elvhqvsmgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthg
kwpvkwyapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermg
cpagcpremydlmnlcwtydvenrpgfaavelrlrnyyydvvneghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbcA (A:)
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilpalkdellaeanvmqqld
npyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkylees
nfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyapecinyyk
fssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlc
wtydvenrpgfaavelrlrnyyydvvne