PDB entry 1x2r

View 1x2r on RCSB PDB site
Description: Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
Class: transcription
Keywords: beta propeller, Structural Genomics, NPPSFA, National Project on Protein Structural and Functional Analyses, RIKEN Structural Genomics/Proteomics Initiative, RSGI, TRANSCRIPTION
Deposited on 2005-04-26, released 2006-03-07
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.191
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kelch-like ECH-associated protein 1
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1x2ra_
  • Chain 'B':
    Compound: Nuclear factor erythroid 2 related factor 2
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1x2rA (A:)
tlhkptqavpcrapkvgrliytaggyfrqslsyleaynpsngswlrladlqvprsglagc
vvggllyavggrnnspdgntdssaldcynpmtnqwspcasmsvprnrigvgvidghiyav
ggshgcihhssveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsae
cyypernewrmitpmntirsgagvcvlhnciyaaggydgqdqlnsverydvetetwtfva
pmrhhrsalgitvhqgkiyvlggydghtfldsvecydpdsdtwsevtrmtsgrsgvgvav
tmepcrkqidqqnctc

    Sequence, based on observed residues (ATOM records): (download) 
    >1x2rA (A:)
vgrliytaggyfrqslsyleaynpsngswlrladlqvprsglagcvvggllyavggrnns
pdgntdssaldcynpmtnqwspcasmsvprnrigvgvidghiyavggshgcihhssvery
eperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitpm
ntirsgagvcvlhnciyaaggydgqdqlnsverydvetetwtfvapmrhhrsalgitvhq
gkiyvlggydghtfldsvecydpdsdtwsevtrmtsgrsgvgvavtmepc

  • Chain 'B':
    No sequence available.