PDB entry 1x2j

View 1x2j on RCSB PDB site
Description: Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
Class: transcription
Keywords: beta propeller, Structural Genomics, NPPSFA, National Project on Protein Structural and Functional Analyses, RIKEN Structural Genomics/Proteomics Initiative, RSGI
Deposited on 2005-04-25, released 2006-03-07
The last revision prior to the SCOP 1.75 freeze date was dated 2006-03-14, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.168
AEROSPACI score: 0.72 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kelch-like ECH-associated protein 1
    Species: MUS MUSCULUS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1x2ja1
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1x2jA (A:)
tlhkptqavpcrapkvgrliytaggyfrqslsyleaynpsngswlrladlqvprsglagc
vvggllyavggrnnspdgntdssaldcynpmtnqwspcasmsvprnrigvgvidghiyav
ggshgcihhssveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsae
cyypernewrmitpmntirsgagvcvlhnciyaaggydgqdqlnsverydvetetwtfva
pmrhhrsalgitvhqgkiyvlggydghtfldsvecydpdsdtwsevtrmtsgrsgvgvav
tmepcrkqidqqnctc

    Sequence, based on observed residues (ATOM records): (download) 
    >1x2jA (A:)
vgrliytaggyfrqslsyleaynpsngswlrladlqvprsglagcvvggllyavggrnns
pdgntdssaldcynpmtnqwspcasmsvprnrigvgvidghiyavggshgcihhssvery
eperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitpm
ntirsgagvcvlhnciyaaggydgqdqlnsverydvetetwtfvapmrhhrsalgitvhq
gkiyvlggydghtfldsvecydpdsdtwsevtrmtsgrsgvgvavtmepc