PDB entry 1wut

View 1wut on RCSB PDB site
Description: Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes
Class: transferase
Keywords: glycogenolysis, type 2 diabetes, TRANSFERASE
Deposited on 2004-12-08, released 2005-12-08
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.26 Å
R-factor: 0.201
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glycogen phosphorylase, muscle form
    Species: Oryctolagus cuniculus [TaxId:9986]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00489
      • conflict (379)
    Domains in SCOPe 2.04: d1wuta_
  • Heterogens: PLP, BN2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1wutA (A:)
srplsdqekrkqisvrglagvenvtelkknfnrhlhftlvkdrnvatprdyyfalahtvr
dhlvgrwirtqqhyyekdpkriyylslefymgrtlqntmvnlalenacdeatyqlgldme
eleeieedaglgngglgrlaacfldsmatlglaaygygiryefgifnqkicggwqmeead
dwlrygnpwekarpeftlpvhfygrvehtsqgakwvdtqvvlampydtpvpgyrnnvvnt
mrlwsakapndfnlkdfnvggyiqavldrnlaenisrvlypndnffegkelrlkqeyfvv
aatlqdiirrfksskfgcrdpvrtnfdafpdkvaiqlndthpslaipelmrvlvdlerld
wdkawevtvktcaytnhtvipealerwpvhlletllprhlqiiyeinqrflnrvaaafpg
dvdrlrrmslveegavkrinmahlciagshavngvarihseilkktifkdfyelephkfq
nktngitprrwlvlcnpglaeiiaerigeeyisdldqlrkllsyvddeafirdvakvkqe
nklkfaaylereykvhinpnslfdvqvkriheykrqllnclhvitlynrikkepnkfvvp
rtvmiggkaapgyhmakmiiklitaigdvvnhdpvvgdrlrviflenyrvslaekvipaa
dlseqistagteasgtgnmkfmlngaltigtmdganvemaeeageenffifgmrvedvdr
ldqrgynaqeyydripelrqiieqlssgffspkqpdlfkdivnmlmhhdrfkvfadyeey
vkcqervsalyknprewtrmvirniatsgkfssdrtiaqyareiwgvepsrqrlpapdek
ip

    Sequence, based on observed residues (ATOM records): (download) 
    >1wutA (A:)
isvrglagvenvtelkknfnrhlhftlvkdrnvatprdyyfalahtvrdhlvgrwirtqq
hyyekdpkriyylslefymgrtlqntmvnlalenacdeatyqlgldmeeleeieedaglg
ngglgrlaacfldsmatlglaaygygiryefgifnqkicggwqmeeaddwlrygnpweka
rpeftlpvhfygrvehtsqgakwvdtqvvlampydtpvpgyrnnvvntmrlwsakapndf
nlkdfnvggyiqavldrnlaenisrvlypndnffegkelrlkqeyfvvaatlqdiirrfk
sstnfdafpdkvaiqlndthpslaipelmrvlvdlerldwdkawevtvktcaytnhtvip
ealerwpvhlletllprhlqiiyeinqrflnrvaaafpgdvdrlrrmslveegavkrinm
ahlciagshavngvarihseilkktifkdfyelephkfqnktngitprrwlvlcnpglae
iiaerigeeyisdldqlrkllsyvddeafirdvakvkqenklkfaaylereykvhinpns
lfdvqvkriheykrqllnclhvitlynrikkepnkfvvprtvmiggkaapgyhmakmiik
litaigdvvnhdpvvgdrlrviflenyrvslaekvipaadlseqistagteasgtgnmkf
mlngaltigtmdganvemaeeageenffifgmrvedvdrldqrgynaqeyydripelrqi
ieqlssgffspkqpdlfkdivnmlmhhdrfkvfadyeeyvkcqervsalyknprewtrmv
irniatsgkfssdrtiaqyareiwgvepsrqrlpap