PDB entry 1wcs

View 1wcs on RCSB PDB site
Description: a mutant of trypanosoma rangeli sialidase displaying trans-sialidase activity
Class: hydrolase
Keywords: trans-sialidase, sialidase, trypanosoma cruzi, trypanosoma rangeli, protein engineering, hydrolase
Deposited on 2004-11-21, released 2004-12-15
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.248
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: sialidase
    Species: Trypanosoma rangeli [TaxId:5698]
    Database cross-references and differences (RAF-indexed):
    • PDB 1WCS (2-2)
      • conflict see remark 9 (52)
      • engineered mutation (98)
      • engineered mutation (100)
      • engineered mutation (122)
      • conflict see remark 9 (179)
      • conflict see remark 9 (188)
      • engineered mutation (251)
      • engineered mutation (286)
      • conflict see remark 9 (374)
      • conflict see remark 9 (412)
      • conflict see remark 9 (608)
    • Uniprot O44049 (3-End)
    Domains in SCOPe 2.06: d1wcsa1, d1wcsa2

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1wcsA (A:)
aaslapgssrvelfkrknstvpfeesngtirervvhsfriptivnvdgvmvaiadaryet
sfdnsfietavkysvddgatwntqiaiknsrassvsrvvdptvivkgnklyilvgsfnkt
rnywtqhrdgsdwepllvvgevtksaangkttatiswgkpvslkplfpaefdgiltkefv
ggvgaaivasngnlvypvqiadmggrvftkimyseddgntwkfaegrskfgcsepavlew
egkliinnrvdynrrlvyessdmgktwvealgtlshvwtnsptsnqpdcqssfvavtieg
krvmlfthplnlkgrwmrdrlhlwmtdnqrifdvgqisigdensgyssvlykddklyslh
eintndvyslvfvrligelqlmksvvrtwkeednhlasictpvvpatppskgacgaavpt
aglvgflshsangsvwedvyrcvdanvanaervpnglkfngvgggavwpvarqgqtrryq
fanyrftlvatvtidelpkgtspllgaglegpgdakllglsydknrqwrplygaapaspt
gswelhkkyhvvltmadrqgsvyvdgqplagsgntvvrgatlpdishfyiggprskgapt
dsrvtvtnvvlynrrlnsseirtlflsqdmigtdggagtaa

    Sequence, based on observed residues (ATOM records): (download) 
    >1wcsA (A:)
aaslapgssrvelfkrknstvpfeesngtirervvhsfriptivnvdgvmvaiadaryet
sfdnsfietavkysvddgatwntqiaiknsrassvsrvvdptvivkgnklyilvgsfnkt
rnywtqhrdgsdwepllvvgevtksaangkttatiswgkpvslkplfpaefdgiltkefv
ggvgaaivasngnlvypvqiadmggrvftkimyseddgntwkfaegrskfgcsepavlew
egkliinnrvdynrrlvyessdmgktwvealgtlshvwtnsptsnqpdcqssfvavtieg
krvmlfthplnlkgrwmrdrlhlwmtdnqrifdvgqisigdensgyssvlykddklyslh
eintndvyslvfvrligelqlmksvvrtwkeednhlasictpvvpaacgaavptaglvgf
lshsangsvwedvyrcvdanvanaervpnglkfngvgggavwpvarqgqtrryqfanyrf
tlvatvtidelpkgtspllgaglegpgdakllglsydknrqwrplygaapasptgswelh
kkyhvvltmadrqgsvyvdgqplagsgntvvrgatlpdishfyiggprskgaptdsrvtv
tnvvlynrrlnsseirtlflsqdmigtd