PDB entry 1wch

View 1wch on RCSB PDB site
Description: crystal structure of ptpl1 human tyrosine phosphatase mutated in colorectal cancer - evidence for a second phosphotyrosine substrate recognition pocket
Class: hydrolase
Keywords: hydrolase, tyrosine phosphatase, phosphate ion, colorectal cancer alternative splicing, coiled coil, cytoskeleton, polymorphism, structural protein
Deposited on 2004-11-16, released 2004-12-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.177
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein tyrosine phosphatase, non-receptor type 13
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1wcha_
  • Heterogens: PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1wchA (A:)
hedsdkdhsfltndelavlpvvkvlpsgkytganlksvirvlrglldqgipskelenlqe
lkpldqcligqtkenrrknryknilpydatrvplgdeggyinasfikipvgkeefvyiac
qgplpttvgdfwqmiweqkstviammtqevegekikcqrywpnilgkttmvsnrlrlalv
rmqqlkgfvvramtlediqtrevrhishlnftawpdhdtpsqpddlltfisymrhihrsg
piithcsagigrsgtlicidvvlglisqdldfdisdlvrcmrlqrhgmvqtedqyifcyq
vilyvltrlqaeeeq

    Sequence, based on observed residues (ATOM records): (download) 
    >1wchA (A:)
hsfltndelavlpvvkvlpsgkytganlksvirvlrglldqgipskelenlqelkpldqc
ligqtkenrrknryknilpydatrvplgdeggyinasfikipvgkeefvyiacqgplptt
vgdfwqmiweqkstviammtqevegekikcqrywpnilgkttmvsnrlrlalvrmqqlkg
fvvramtlediqtrevrhishlnftawpdhdtpsqpddlltfisymrhihrsgpiithcs
agigrsgtlicidvvlglisqdldfdisdlvrcmrlqrhgmvqtedqyifcyqvilyvlt
rlqaeeeq