PDB entry 1wch

View 1wch on RCSB PDB site
Description: Crystal structure of PTPL1 human tyrosine phosphatase mutated in colorectal cancer - evidence for a second phosphotyrosine substrate recognition pocket
Class: hydrolase
Keywords: hydrolase, tyrosine phosphatase, phosphate ion, colorectal cancer alternative splicing, coiled coil, cytoskeleton, polymorphism, structural protein
Deposited on 2004-11-16, released 2004-12-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-16, with a file datestamp of 2019-10-11.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein tyrosine phosphatase, non-receptor type 13
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1wcha_
  • Heterogens: PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1wchA (A:)
hedsdkdhsfltndelavlpvvkvlpsgkytganlksvirvlrglldqgipskelenlqe
lkpldqcligqtkenrrknryknilpydatrvplgdeggyinasfikipvgkeefvyiac
qgplpttvgdfwqmiweqkstviammtqevegekikcqrywpnilgkttmvsnrlrlalv
rmqqlkgfvvramtlediqtrevrhishlnftawpdhdtpsqpddlltfisymrhihrsg
piithcsagigrsgtlicidvvlglisqdldfdisdlvrcmrlqrhgmvqtedqyifcyq
vilyvltrlqaeeeq

    Sequence, based on observed residues (ATOM records): (download) 
    >1wchA (A:)
hsfltndelavlpvvkvlpsgkytganlksvirvlrglldqgipskelenlqelkpldqc
ligqtkenrrknryknilpydatrvplgdeggyinasfikipvgkeefvyiacqgplptt
vgdfwqmiweqkstviammtqevegekikcqrywpnilgkttmvsnrlrlalvrmqqlkg
fvvramtlediqtrevrhishlnftawpdhdtpsqpddlltfisymrhihrsgpiithcs
agigrsgtlicidvvlglisqdldfdisdlvrcmrlqrhgmvqtedqyifcyqvilyvlt
rlqaeeeq