PDB entry 1w96

View 1w96 on RCSB PDB site
Description: crystal structure of biotin carboxylase domain of acetyl-coenzyme a carboxylase from saccharomyces cerevisiae in complex with soraphen a
Class: ligase
Keywords: obesity, diabetes, fatty acid metabolism, structure-based drug design, allosteric inhibition, polyketide
Deposited on 2004-10-06, released 2005-01-04
The last revision prior to the SCOP 1.73 freeze date was dated 2005-03-31, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.195
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: acetyl-coenzyme a carboxylase
    Species: SACCHAROMYCES CEREVISIAE
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1w96a1, d1w96a2, d1w96a3
  • Chain 'B':
    Compound: acetyl-coenzyme a carboxylase
    Species: SACCHAROMYCES CEREVISIAE
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1w96b1, d1w96b2, d1w96b3
  • Chain 'C':
    Compound: acetyl-coenzyme a carboxylase
    Species: SACCHAROMYCES CEREVISIAE
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1w96c1, d1w96c2, d1w96c3
  • Heterogens: S1A, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1w96A (A:)
kmeyeitnyserhtelpghfiglntvdkleesplrdfvkshgghtviskilianngiaav
keirsvrkwayetfgddrtvqfvamatpedleanaeyirmadqyievpggtnnnnyanvd
livdiaeradvdavwagwghasenpllpeklsqskrkvifigppgnamrslgdkisstiv
aqsakvpcipwsgtgvdtvhvdektglvsvdddiyqkgcctspedglqkakrigfpvmik
aseggggkgirqvereedfialyhqaaneipgspifimklagrarhlevqlladqygtni
slfgrdcsvqrrhqkiieeapvtiakaetfhemekaavrlgklvgyvsagtveylyshdd
gkfyflelnprlqvehpttemvsgvnlpaaqlqiamgipmhrisdirtlygmnphsasei
dfefktqdatkkqrrpipkghctacritsedpndgfkpsggtlhelnfrsssnvwgyfsv
gnngnihsfsdsqfghifafgenrqasrkhmvvalkelsirgdfrttveyliklletedf
edntittgwlddli

    Sequence, based on observed residues (ATOM records): (download) 
    >1w96A (A:)
meyeitnyserhtelpghfiglntvdkleesplrdfvkshgghtviskilianngiaavk
eirsvrkwayetfgddrtvqfvamatpedleanaeyirmadqyievpggtnnnnyanvdl
ivdiaeradvdavwagwghasenpllpeklsqskrkvifigppgnamrslgdkisstiva
qsakvpcipwsgtgvdtvhvdektglvsvdddiyqkgcctspedglqkakrigfpvmika
seggggkgirqvereedfialyhqaaneipgspifimklagrarhlevqlladqygtnis
lfgrdcsvqrrhqkiieeapvtiakaetfhemekaavrlgklvgyvsagtveylyshddg
kfyflelnprlqvehpttemvsgvnlpaaqlqiamgipmhrisdirtlygmnphsaseid
fefktqdatkkqrrpipkghctacritsedpndgfkpsggtlhelnfrsssnvwgyfsvg
nngnihsfsdsqfghifafgenrqasrkhmvvalkelsirgtveyliklletedfednti
ttgwlddli

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1w96B (B:)
kmeyeitnyserhtelpghfiglntvdkleesplrdfvkshgghtviskilianngiaav
keirsvrkwayetfgddrtvqfvamatpedleanaeyirmadqyievpggtnnnnyanvd
livdiaeradvdavwagwghasenpllpeklsqskrkvifigppgnamrslgdkisstiv
aqsakvpcipwsgtgvdtvhvdektglvsvdddiyqkgcctspedglqkakrigfpvmik
aseggggkgirqvereedfialyhqaaneipgspifimklagrarhlevqlladqygtni
slfgrdcsvqrrhqkiieeapvtiakaetfhemekaavrlgklvgyvsagtveylyshdd
gkfyflelnprlqvehpttemvsgvnlpaaqlqiamgipmhrisdirtlygmnphsasei
dfefktqdatkkqrrpipkghctacritsedpndgfkpsggtlhelnfrsssnvwgyfsv
gnngnihsfsdsqfghifafgenrqasrkhmvvalkelsirgdfrttveyliklletedf
edntittgwlddli

    Sequence, based on observed residues (ATOM records): (download) 
    >1w96B (B:)
kmeyeitnyserhtelpghfiglntvdkleesplrdfvkshgghtviskilianngiaav
keirsvrkwayetfgddrtvqfvamatpedleanaeyirmadqyievpggtnnnnyanvd
livdiaeradvdavwagwghasenpllpeklsqskrkvifigppgnamrslgdkisstiv
aqsakvpcipwsgtgvdtvhvdektglvsvdddiyqkgcctspedglqkakrigfpvmik
aseggggkgirqvereedfialyhqaaneipgspifimklagrarhlevqlladqygtni
slfgrdcsvqrrhqkiieeapvtiakaetfhemekaavrlgklvgyvsagtveylyshdd
gkfyflelnprlqvehpttemvsgvnlpaaqlqiamgipmhrisdirtlygmnphsasei
dfefktqdatkkqrrpipkghctacritgtlhelnfrsssnvwgyfsvgnngnihsfsds
qfghifafgenrqasrkhmvvalkelsirgdfrttveyliklletedfedntittgwldd
li

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1w96C (C:)
kmeyeitnyserhtelpghfiglntvdkleesplrdfvkshgghtviskilianngiaav
keirsvrkwayetfgddrtvqfvamatpedleanaeyirmadqyievpggtnnnnyanvd
livdiaeradvdavwagwghasenpllpeklsqskrkvifigppgnamrslgdkisstiv
aqsakvpcipwsgtgvdtvhvdektglvsvdddiyqkgcctspedglqkakrigfpvmik
aseggggkgirqvereedfialyhqaaneipgspifimklagrarhlevqlladqygtni
slfgrdcsvqrrhqkiieeapvtiakaetfhemekaavrlgklvgyvsagtveylyshdd
gkfyflelnprlqvehpttemvsgvnlpaaqlqiamgipmhrisdirtlygmnphsasei
dfefktqdatkkqrrpipkghctacritsedpndgfkpsggtlhelnfrsssnvwgyfsv
gnngnihsfsdsqfghifafgenrqasrkhmvvalkelsirgdfrttveyliklletedf
edntittgwlddli

    Sequence, based on observed residues (ATOM records): (download) 
    >1w96C (C:)
meyeitnyserhtelpghfiglntvdkleesplrdfvkshgghtviskilianngiaavk
eirsvrkwayetfgddrtvqfvamatpedleanaeyirmadqyievpggtnnnnyanvdl
ivdiaeradvdavwagwghasenpllpeklsqskrkvifigppgnamrslgdkisstiva
qsakvpcipwsgtgvdtvhvdektglvsvdddiyqkgcctspedglqkakrigfpvmika
seggggkgirqvereedfialyhqaaneipgspifimklagrarhlevqlladqygtnis
lfgrdcsvqrrhqkiieeapvtiakaetfhemekaavrlgklvgyvsagtveylyshddg
kfyflelnprlqvehpttemvsgvnlpaaqlqiamgipmhrisdirtlygmnphsaseid
fefktqdatkkqrrpipkghctacritsedpndgfkpsggtlhelnfrsssnvwgyfsvg
nngnihsfsdsqfghifafgenrqasrkhmvvalkelsirgdfrttveylikllete