PDB entry 1w6k

View 1w6k on RCSB PDB site
Description: structure of human osc in complex with lanosterol
Class: isomerase
Keywords: cyclase, cholesterol, lanosterol, monotopic membrane protein, b-octyl-glucoside, isomerase, steroid biosynthesis
Deposited on 2004-08-19, released 2004-10-29
The last revision prior to the SCOP 1.73 freeze date was dated 2004-12-23, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.147
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lanosterol synthase
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1w6ka1, d1w6ka2
  • Heterogens: BOG, LAN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1w6kA (A:)
mtegtclrrrggpyktepatdlgrwrlncergrqtwtylqderagreqtgleayalgldt
knyfkdlpkahtafegalngmtfyvglqaedghwtgdyggplfllpgllitchvariplp
agyreeivrylrsvqlpdggwglhiedkstvfgtalnyvslrilgvgpddpdlvrarnil
hkkggavaipswgkfwlavlnvysweglntlfpemwlfpdwapahpstlwchcrqvylpm
sycyavrlsaaedplvqslrqelyvedfasidwlaqrnnvapdelytphswllrvvyall
nlyehhhsahlrqravqklyehivaddrftksisigpisktinmlvrwyvdgpastafqe
hvsripdylwmgldgmkmqgtngsqiwdtafaiqalleagghhrpefssclqkaheflrl
sqvpdnppdyqkyyrqmrkggfsfstldcgwivsdctaealkavlllqekcphvtehipr
erlcdavavllnmrnpdggfatyetkrgghllellnpsevfgdimidytyvectsavmqa
lkyfhkrfpehraaeiretltqglefcrrqqradgswegswgvcftygtwfgleafacmg
qtyrdgtacaevsracdfllsrqmadggwgedfesceerryvqsaqsqihntcwammglm
avrhpdieaqergvrcllekqlpngdwpqeniagvfnkscaisytsyrnifpiwalgrfs
qlyperalaghp

    Sequence, based on observed residues (ATOM records): (download) 
    >1w6kA (A:)
clrrrggpyktepatdlgrwrlncergrqtwtylqdagreqtgleayalgldtknyfkdl
pkahtafegalngmtfyvglqaedghwtgdyggplfllpgllitchvariplpagyreei
vrylrsvqlpdggwglhiedkstvfgtalnyvslrilgvgpddpdlvrarnilhkkggav
aipswgkfwlavlnvysweglntlfpemwlfpdwapahpstlwchcrqvylpmsycyavr
lsaaedplvqslrqelyvedfasidwlaqrnnvapdelytphswllrvvyallnlyehhh
sahlrqravqklyehivaddrftksisigpisktinmlvrwyvdgpastafqehvsripd
ylwmgldgmkmqgtngsqiwdtafaiqalleagghhrpefssclqkaheflrlsqvpdnp
pdyqkyyrqmrkggfsfstldcgwivsdctaealkavlllqekcphvtehiprerlcdav
avllnmrnpdggfatyetkrgghllellnpsevfgdimidytyvectsavmqalkyfhkr
fpehraaeiretltqglefcrrqqradgswegswgvcftygtwfgleafacmgqtyrdgt
acaevsracdfllsrqmadggwgedfesceerryvqsaqsqihntcwammglmavrhpdi
eaqergvrcllekqlpngdwpqeniagvfnkscaisytsyrnifpiwalgrfsqlypera
laghp