PDB entry 1w6f

View 1w6f on RCSB PDB site
Description: arylamine n-acetyltransferase from mycobacterium smegmatis with the anti-tubercular drug isoniazid bound in the active site.
Class: transferase
Keywords: nat,tuberculosis,acetyltransferase,transferase
Deposited on 2004-08-17, released 2005-02-23
The last revision prior to the SCOP 1.73 freeze date was dated 2005-02-23, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.1825
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: arylamine n-acetyltransferase
    Species: Mycobacterium smegmatis
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1w6fa1
  • Chain 'B':
    Compound: arylamine n-acetyltransferase
    Species: Mycobacterium smegmatis
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1w6fb1
  • Chain 'C':
    Compound: arylamine n-acetyltransferase
    Species: Mycobacterium smegmatis
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1w6fc1
  • Chain 'D':
    Compound: arylamine n-acetyltransferase
    Species: Mycobacterium smegmatis
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1w6fd1
  • Heterogens: ISZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1w6fA (A:)
eshmamdlggyltrigldgrprpdlgtlhaivaahnrsipfenldpllgipvadlsaeal
faklvdrrrggycyehngllgyvleelgfeverlsgrvvwmraddaplpaqthnvlsvav
pgadgrylvdvgfggqtltspirleagpvqqtrhepyrltrhgddhtlaaqvrgewqply
tftteprpridlevgswyvsthpgshfvtgltvavvtddarynlrgrnlavhrsgatehi
rfdsaaqvldaivnrfgidlgdlagrdvqarvaevldt

    Sequence, based on observed residues (ATOM records): (download) 
    >1w6fA (A:)
mdlggyltrigldgrprpdlgtlhaivaahnrsipfenldpllgipvadlsaealfaklv
drrrggycyehngllgyvleelgfeverlsgrvvwmraddaplpaqthnvlsvavpgadg
rylvdvgfggqtltspirleagpvqqtrhepyrltrhgddhtlaaqvrgewqplytftte
prpridlevgswyvsthpgshfvtgltvavvtddarynlrgrnlavhrsgatehirfdsa
aqvldaivnrfgidlgdlagrdvqarvaevldt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1w6fB (B:)
eshmamdlggyltrigldgrprpdlgtlhaivaahnrsipfenldpllgipvadlsaeal
faklvdrrrggycyehngllgyvleelgfeverlsgrvvwmraddaplpaqthnvlsvav
pgadgrylvdvgfggqtltspirleagpvqqtrhepyrltrhgddhtlaaqvrgewqply
tftteprpridlevgswyvsthpgshfvtgltvavvtddarynlrgrnlavhrsgatehi
rfdsaaqvldaivnrfgidlgdlagrdvqarvaevldt

    Sequence, based on observed residues (ATOM records): (download) 
    >1w6fB (B:)
gyltrigldgrprpdlgtlhaivaahnrsipfenldpllgipvadlsaealfaklvdrrr
ggycyehngllgyvleelgfeverlsgrvvwmraddaplpaqthnvlsvavpgadgrylv
dvgfggqtltspirleagpvqqtrhepyrltrhgddhtlaaqvrgewqplytftteprpr
idlevgswyvsthpgshfvtgltvavvtddarynlrgrnlavhrsgatehirfdsaaqvl
daivnrfgidlgdlagrdvqarvaevldt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1w6fC (C:)
eshmamdlggyltrigldgrprpdlgtlhaivaahnrsipfenldpllgipvadlsaeal
faklvdrrrggycyehngllgyvleelgfeverlsgrvvwmraddaplpaqthnvlsvav
pgadgrylvdvgfggqtltspirleagpvqqtrhepyrltrhgddhtlaaqvrgewqply
tftteprpridlevgswyvsthpgshfvtgltvavvtddarynlrgrnlavhrsgatehi
rfdsaaqvldaivnrfgidlgdlagrdvqarvaevldt

    Sequence, based on observed residues (ATOM records): (download) 
    >1w6fC (C:)
dlggyltrigldgrprpdlgtlhaivaahnrsipfenldpllgipvadlsaealfaklvd
rrrggycyehngllgyvleelgfeverlsgrvvwmraddaplpaqthnvlsvavpgadgr
ylvdvgfggqtltspirleagpvqqtrhepyrltrhgddhtlaaqvrgewqplytfttep
rpridlevgswyvsthpgshfvtgltvavvtddarynlrgrnlavhrsgatehirfdsaa
qvldaivnrfgidlgdlagrdvqarvaevldt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1w6fD (D:)
eshmamdlggyltrigldgrprpdlgtlhaivaahnrsipfenldpllgipvadlsaeal
faklvdrrrggycyehngllgyvleelgfeverlsgrvvwmraddaplpaqthnvlsvav
pgadgrylvdvgfggqtltspirleagpvqqtrhepyrltrhgddhtlaaqvrgewqply
tftteprpridlevgswyvsthpgshfvtgltvavvtddarynlrgrnlavhrsgatehi
rfdsaaqvldaivnrfgidlgdlagrdvqarvaevldt

    Sequence, based on observed residues (ATOM records): (download) 
    >1w6fD (D:)
ggyltrigldgrprpdlgtlhaivaahnrsipfenldpllgipvadlsaealfaklvdrr
rggycyehngllgyvleelgfeverlsgrvvwmraddaplpaqthnvlsvavpgadgryl
vdvgfggqtltspirleagpvqqtrhepyrltrhgddhtlaaqvrgewqplytftteprp
ridlevgswyvsthpgshfvtgltvavvtddarynlrgrnlavhrsgatehirfdsaaqv
ldaivnrfgidlgdlagrdvqarvaevld